Aug 1, 2008

A prospective study of telomere length and the risk of skin cancer

The Journal of Investigative Dermatology
Jiali HanImmaculata De Vivo

Abstract

Telomere length is important in tumorigenesis. Using quantitative real-time PCR, we prospectively measured relative telomere length in a nested case-control study within the Nurses' Health Study: 218 melanoma cases, 285 squamous-cell carcinoma (SCC) cases, 300 basal-cell carcinoma (BCC) cases, and 870 controls. We observed that shorter telomeres were associated with a decreased number of moles (P=0.002) and a decreased risk of melanoma. Women in the second and first quartiles, those with the shortest telomere length, had an odds ratio (OR) for melanoma of 0.54 (95% confidence interval (CI), 0.29-1.01) and 0.59 (95% CI, 0.31-1.13), respectively, compared with those in the fourth quartile (P, trend=0.09). There was no clear trend between telomere length and SCC risk. In contrast, we found that shorter telomere length was associated with an increased risk of BCC. Compared with those in the fourth quartile, women in the first quartile had an OR of 1.85 (95% CI, 0.94-3.62) (P, trend=0.09). The opposing associations observed should be interpreted with caution, and further research is needed to confirm these possible associations.

  • References36
  • Citations105

References

  • References36
  • Citations105

Citations

Mentioned in this Paper

Malignant Neoplasm of Skin
Real-Time Polymerase Chain Reaction
Nevus
Talpidae
Pigmented Basal Cell Carcinoma
Reverse Transcriptase Polymerase Chain Reaction
Melanoma vaccine
Telomere
Squamous Cell Carcinoma
Nested Case-Control Studies

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