A prospective study of the factors shaping antibody responses to the AS03-adjuvanted influenza A/H1N1 vaccine in cancer outpatients.

The Oncologist
Andreas F HottingerH1N1 Study Group

Abstract

To identify the determinants of antibody responses to adjuvanted influenza A/H1N1/09 vaccines in a cohort of cancer outpatients. Patients with cancer and controls were enrolled in a prospective single-center field study. Two doses of AS03-adjuvanted pandemic influenza vaccine were administered to patients and one dose was administered to controls. Antibody responses were measured using hemagglutination inhibition and confirmed by microneutralization. Geometric mean titers (GMTs) and seroprotection rates (defined as GMTs ≥40) were compared. Immunizations were safe and well tolerated in 197 cancer patients (lymphoma, 57; glioma, 26; lung or head and neck, 37; gastrointestinal, 41; breast, 36) and 138 controls. Similar seroprotection rates (82.3% versus 87%) and GMTs (336.9 versus 329.9) were achieved after two doses of adjuvanted vaccine in cancer patients and one dose in controls. Univariate analyses identified older age, prior immunization against seasonal influenza, lymphoma, CD4 count, active chemotherapy, and rituximab and steroid treatments as being associated with weaker antibody responses. However, only age and chemotherapy plus rituximab remained independent determinants of vaccine responses in multivariate analyses. Two...Continue Reading

References

Feb 26, 1977·The Medical Journal of Australia·B J FeeryM G Evered
Nov 1, 1977·Annals of Internal Medicine·D W OrtbalsJ Y Lee
Jul 1, 1989·The Journal of Pediatrics·A KempeE Katsanis
Sep 1, 1966·The Journal of Experimental Medicine· Fazekas de St Groth, R G Webster
Jan 1, 1982·Archives of Internal Medicine·W H Barker, J P Mullooly
May 1, 1995·Supportive Care in Cancer : Official Journal of the Multinational Association of Supportive Care in Cancer·L S EltingG P Bodey
Jan 1, 1994·Acta Haematologica·D A GribabisG A Pangalis
Jul 2, 1999·British Journal of Cancer·H AndersonM Zambon
Mar 17, 1997·The American Journal of Medicine·R B CouchE Whimbey
Jan 9, 2001·Supportive Care in Cancer : Official Journal of the Multinational Association of Supportive Care in Cancer·L B BrydakS S Góźdź
Nov 1, 2002·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Ramesh K RamanathanDonald L Trump
Jul 12, 2005·Pediatric Blood & Cancer·Akinobu MatsuzakiToshiro Hara
Nov 24, 2005·Clinical Medicine & Research·Joseph J MazzaKurt D Reed
Mar 9, 2007·Journal of Clinical Immunology·Piotr CentkowskiUNKNOWN Polish Lymphoma Research Group
Apr 20, 2007·The Cochrane Database of Systematic Reviews·T O JeffersonV Demicheli
Aug 4, 2009·The Journal of Immunology : Official Journal of the American Association of Immunologists·Jin Hyang KimJoshy Jacob
Sep 12, 2009·The New England Journal of Medicine·Tristan W ClarkIain Stephenson
Nov 26, 2009·Biogerontology·Alexander AdemokunDeborah Dunn-Walters
Apr 14, 2010·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Daniel A PollyeaSandra J Horning
Jun 1, 2010·Annals of Oncology : Official Journal of the European Society for Medical Oncology·L A HajjarP M Hoff
Oct 19, 2010·Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation·Nicolas C IssaLindsey R Baden
Dec 3, 2010·Emerging Infectious Diseases·Catherine LiuW Lawrence Drew
Dec 21, 2010·Journal of Clinical Virology : the Official Publication of the Pan American Society for Clinical Virology·Helen J MackayAmit M Oza
Feb 10, 2011·Annals of Oncology : Official Journal of the European Society for Medical Oncology·A Meerveld-EgginkD H Biesma
Mar 19, 2011·Pediatric Hematology and Oncology·Nihal OzdemirInci Yıldız
Apr 19, 2011·The Journal of Immunology : Official Journal of the American Association of Immunologists·Davide BedognettiAndrea De Maria
Apr 22, 2011·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Ake OrtqvistBo Svenungsson
May 18, 2011·Annals of Oncology : Official Journal of the European Society for Medical Oncology·B RousseauC Tournigand

❮ Previous
Next ❯

Citations

Nov 22, 2013·Current Infectious Disease Reports·Aliyah Baluch, Yanina Pasikhova
Feb 2, 2013·The Oncologist·Leslie S KersunKathleen E Sullivan
Mar 13, 2014·Annals of Oncology : Official Journal of the European Society for Medical Oncology·P PedrazzoliUNKNOWN Italian Society of Medical Oncology
Nov 27, 2014·Human Vaccines & Immunotherapeutics·Yuichiro IdeYoshio Hirota
May 8, 2018·Oncology Research and Treatment·Marie von Lilienfeld-Toal, Georg Maschmeyer
Mar 3, 2020·Frontiers in Oncology·Valérie DutoitPierre-Yves Dietrich
Feb 13, 2019·The Lancet Infectious Diseases·Malgorzata MikulskaUNKNOWN European Conference on Infections in Leukaemia group
Jul 10, 2021·Reviews in Endocrine & Metabolic Disorders·Frederick Vogel, Martin Reincke
Nov 20, 2021·Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer·Valérie GounantGérard Zalcman
Dec 31, 2021·The Korean Journal of Pain·Sung Man HongEun Joo Choi

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cancer Vaccines

Cancer vaccines are vaccines that either treat existing cancer or prevent development of a cancer.

B-Cell Leukemia (Keystone)

B-cell leukemia includes various types of lymphoid leukemia that affect B cells. Here is the latest research on B-cell leukemia.

Related Papers

European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology
W LoG P Bodey
Cancer Chemotherapy and Pharmacology
Ajithkumar PuthillathMarwan G Fakih
Journal of Oncology Pharmacy Practice : Official Publication of the International Society of Oncology Pharmacy Practitioners
Abigail L SommerJudith A Smith
© 2022 Meta ULC. All rights reserved