A prospective study of the impact of subthreshold mixed states on the 24-month clinical outcomes of bipolar I disorder or schizoaffective disorder

Journal of Affective Disorders
S DoddM Berk

Abstract

The clinical significance of subthreshold mixed states is unclear. This study investigated the clinical outcomes in participants with bipolar I disorder or schizoaffective disorder, using the Cassidy and Benazzi criteria for manic and depressive mixed states, respectively. Participants (N=239) in a prospective observational study of treatment and outcomes in bipolar I or schizoaffective disorder, bipolar type, were grouped based on study entry clinical presentation as having pure depression (n=63) if they satisfied DSM-IV-TR criteria for a Major Depressive Episode (MDE), depressive mixed state if they also had at least three concurrent hypomanic symptoms (n=33), or not depressed (n=143) if they did not satisfy the criteria for MDE. Participants were similarly grouped as having pure mania (n=3) if they satisfied DSM-IV criteria for a Manic Episode, manic mixed state if they also had at least two concurrent depressive symptoms (n=33), or not manic (n=203). Clinical data were collected by interview every 3 months over a 24-month period. Measures of quality of life, mental and physical health over the 24-month period were significantly worse for participants who were classified as having mixed states at study entry on most outcome ...Continue Reading

References

Jul 1, 1988·Journal of Affective Disorders·R F PrienD J Kupfer
Jan 1, 1987·The American Journal of Psychiatry·S K SecundaS Chang
Sep 1, 1994·The American Journal of Psychiatry·S C DilsaverK J Krajewski
Apr 1, 1993·The Journal of Nervous and Mental Disease·M B KellerT I Mueller
Oct 1, 1993·The American Journal of Psychiatry·S C DilsaverM T Halle
Nov 7, 1999·The Psychiatric Clinics of North America·A Koukopoulos, A Koukopoulos
May 29, 2000·Psychological Medicine·F CassidyB J Carroll
Mar 21, 2001·Bipolar Disorders·F Cassidy, B J Carroll
Nov 28, 2002·Progress in Neuro-psychopharmacology & Biological Psychiatry·Franco Benazzi
Jan 14, 2003·Comprehensive Psychiatry·Franco Benazzi
Mar 31, 2005·European Psychiatry : the Journal of the Association of European Psychiatrists·Eduard Vieta
Jun 10, 2005·Journal of Affective Disorders·Steven C DilsaverHagop S Akiskal
Nov 30, 2005·Psychiatry Research·Franco Benazzi, Hagop S Akiskal
Dec 1, 2005·The International Journal of Neuropsychopharmacology·Gian Paolo MinnaiRoss J Baldessarini
Jan 24, 2007·Journal of Affective Disorders·Chantal HenryEduard Vieta
Feb 28, 2007·Journal of Affective Disorders·M BerkJ Kulkarni
Apr 13, 2007·Journal of Affective Disorders·Dörthe RöttigAndreas Marneros
Jul 7, 2007·Journal of Affective Disorders·Hari Mandir Kaur KhalsaRoss J Baldessarini
Sep 25, 2007·Journal of Affective Disorders·Jayashri KulkarniSeetal Dodd

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Citations

Apr 25, 2012·Bipolar Disorders·Gin S MalhiMichael Gitlin
Sep 27, 2014·Journal of Child Psychology and Psychiatry, and Allied Disciplines·Vanessa Sanchez-GistauJosefina Castro-Fornieles
Dec 17, 2011·Journal of Affective Disorders·Chi-Un PaeS Nassir Ghaemi
Apr 26, 2011·Journal of Affective Disorders·Isabella PacchiarottiFrancesc Colom
Feb 3, 2012·International Journal of Psychiatry in Clinical Practice·Marianna MazzaLuigi Janiri
Aug 12, 2014·Journal of Affective Disorders·Mark ZimmermanJennifer H Martinez
Nov 26, 2013·Current Opinion in Psychiatry·David J Castle
May 28, 2019·Journal of Affective Disorders·Luisa WeinerSébastien Weibel
Aug 28, 2021·International Journal of Environmental Research and Public Health·Jose Manuel MontesCristina Jenaro

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