PMID: 8473421Feb 1, 1993Paper

A prospective study to evaluate the efficacy of modified swim-up preparation for male sex selection

Human Reproduction
J H Check, D Katsoff

Abstract

A previously published study reporting the use of a modified swim-up technique for sperm preparation prior to insemination which resulted in a high percentage of male births has been criticized for its lack of controls. The present prospective study was initiated to investigate further the efficacy of modified swim-up preparation for male sex-selection when applied in a properly defined control group. Our results showed that the proportion of males born in singleton pregnancies was approximately 50% in the group inseminated following sperm preparation with Percoll and in the control group with no sperm preparation compared with 88.5% in the group treated with the modified method of swim-up sperm preparation prior to insemination. This high rate of males in the group treated with modified swim-up was also observed in singleton pregnancies of women taking ovulation inducing drugs (primarily clomiphene citrate). This contrasts with previous publications in which a higher rate of females was found in clomiphene citrate patients using the albumin separation technique. How the mechanism of the swim-up procedure may result in a high male birth rate remains unclear. A high percentage of y enriched semen was found using fluorochrome qui...Continue Reading

Citations

Mar 4, 1999·The Journal of Obstetrics and Gynaecology Research·P Li, H Hoshiai
Aug 14, 2012·International Journal of Andrology·S Koundouros, P Verma
Apr 16, 2003·Haemophilia : the Official Journal of the World Federation of Hemophilia·J E PeñaM V Sauer
Nov 20, 2016·Annals of the New York Academy of Sciences·Elissa Z CameronLaura M Parsley
Oct 3, 2019·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·John F Mulley
May 31, 2016·Reproduction, Fertility, and Development·A M Edwards, E Z Cameron

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