PMID: 11342915May 9, 2001Paper

A prospective study to evaluate the role of complexed prostate specific antigen and free/total prostate specific antigen ratio for the diagnosis of prostate cancer

The Journal of Urology
I D MitchellI Ross

Abstract

Patients are increasingly undergoing prostatic biopsy to identify localized prostate cancer. The decision to perform a biopsy is often made on the basis of total prostate specific antigen (PSA). However, this value lacks adequate specificity for this task. We evaluate the role that a number of these tests, including the Bayer complexed PSA (Bayer Diagnostics, Tarrytown, New York) and free/total PSA ratio, may have in our clinical practice. A total of 160 consecutive patients attending a prostate assessment clinic were enrolled during an 18-month period in our study. All patients had a previously recorded total PSA (range 2.6 to 20.0 ng./ml.). Before transrectal ultrasound biopsy of the prostate gland, a blood sample was taken with patient consent. The findings on ultrasound were then recorded, including prostate volume. Serum samples were immediately sent for subsequent storage and analysis. Of the patients enrolled 109 had benign histology while 51 had prostatic carcinoma. The 2 patient groups were well matched for age. In our series patients with prostate cancer had significantly smaller prostates and higher mean total PSA. At a high sensitivity, such as 95%, it appeared that Bayer complexed PSA performed better than the othe...Continue Reading

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Citations

Oct 26, 2011·European Journal of Medical Research·F StrittmatterR Waidelich
Aug 2, 2011·Canadian Urological Association Journal = Journal De L'Association Des Urologues Du Canada·Jonathan I IzawaAlla E Iansavichene
Oct 14, 2004·World Journal of Urology·Hessel WijkstraJean J M C H de la Rosette
May 12, 2004·Urology·J Kellogg Parsons, Alan W Partin
Aug 3, 2006·International Journal of Urology : Official Journal of the Japanese Urological Association·Ronan LongKevin Moran
Dec 4, 2019·Journal of Drug Targeting·Mehwish Saba Aslam, Liudi Yuan

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