A prospective surveillance study for multidrug-resistant bacteria colonization in hospitalized patients at a Thai University Hospital

Antimicrobial Resistance and Infection Control
Pinyo RattanaumpawanVisanu Thamlikitkul

Abstract

Colonization with multidrug-resistant (MDR) bacteria is a major risk factor for developing subsequent MDR infections. We performed a prospective surveillance study in hospitalized patients at Siriraj Hospital. Nasal cavity, throat, inguinal area and rectal swabs were obtained within the first 48-h after admission, on day-5 after hospitalization and then every 7 days until discharge. Target bacteria included extended-spectrum beta-lactamase-producing Enterobacteriaceae (ESBL), carbapenem-resistant-P.aeruginosa (CR-PA), carbapenem-resistant-A.baumannii (CR-AB) and methicillin-resistant S.aureus (MRSA). From January 2013-December 2014, 487 patients were enrolled. The baseline prevalence of colonization by ESBL, CR-PA, CR-AB and MRSA at any site was 52.2%, 6.8%, 4.7% and 7.2%, respectively. After 3-week of hospitalization, the prevalence of colonization by ESBL, CR-PA, CR-AB and MRSA increased to 71.7%, 47.2%, 18.9% and 18.9%, respectively. Multivariable analysis revealed that diabetes mellitus and recent cephalosporin exposure were the independent risk factors for baseline colonization by ESBL. The independent risk factors for CR-AB and/or CR-PA colonization were cerebrovascular diseases, previous hospitalization, transfer from an...Continue Reading

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Citations

Oct 1, 2019·Current Opinion in Infectious Diseases·Almudena BurilloEmilio Bouza
Jun 12, 2019·Infection Control and Hospital Epidemiology : the Official Journal of the Society of Hospital Epidemiologists of America·Isabelle Vock, Sarah Tschudin-Sutter
Oct 9, 2019·International Journal of Environmental Research and Public Health·Visanu ThamlikitkulWilai Chiemchaisri
Nov 3, 2020·Journal of Infection and Chemotherapy : Official Journal of the Japan Society of Chemotherapy·Kanit AssawatheptaweePannika R Niumsup
May 27, 2021·Expert Review of Anti-infective Therapy·Zikria SaleemMuhammad Azmi Hassali

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