A prospective trial comparing oocyte donor ovarian response and recipient pregnancy rates between suppression with gonadotrophin-releasing hormone agonist (GnRHa) alone and dual suppression with a contraceptive vaginal ring and GnRH

Human Reproduction
F MartinezP N Barri

Abstract

Contraceptive treatment before gonadotrophin-releasing hormone agonist administration presents advantages in women with a tendency to hyper-response and simplifies donor-recipient treatment synchronization. This study compares response to gonadotrophin stimulation under hypophyseal suppression in oocyte donors with or without vaginal contraceptive pretreatment. One hundred and ninety oocyte donors were recruited in a single centre and prospectively assigned to one of two treatment groups, according to the day of the week menstruation initiated: Group VC-, no prior vaginal contraceptive and Group VC+, prior vaginal contraceptive. VC+ patients presented a significantly higher cancellation rate, lower plasma estradiol levels and fewer follicles >12 mm on the day of hCG, versus the VC- group. Number of oocytes recovered was significantly lower in the VC+ group. All the cases of severe ovarian hyperstimulation syndrome (SOHSS) were in the VC- group. Pregnancy rates by embryo transfer to synchronic recipients were similar between VC+ and VC- (59.5 versus 57.9%, respectively). Vaginal contraceptive pretreatment resulted in a higher ovarian suppression, whereas SOHSS rate was lower than in donors who did not receive pretreatment. There...Continue Reading

References

Feb 1, 1990·Fertility and Sterility·Y GonenR F Casper
Jan 1, 1988·Annals of the New York Academy of Sciences·S MashiachB Goldman

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Citations

Nov 26, 2013·Reproductive Biomedicine Online·Pedro N BarriIgnacio Rodriguez
Apr 22, 2014·Reproductive Biomedicine Online·Manuel AlvarezPedro N Barri
Nov 26, 2011·Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology·Dalia Beatriz Rodríguez BarredoPedro Nolasc Barri Rague
Apr 3, 2008·Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology·Francisca MartínezBuenaventura Coroleu
Feb 7, 2012·Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology·Elisabet CluaPere N Barri
Oct 23, 2015·Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology·Elisabet CluaRosa Tur
Oct 17, 2012·Reproductive Biomedicine Online·Elisabet CluaAnna Veiga
Oct 1, 2010·Reproductive Biomedicine Online·Elisabet CluaAnna Veiga
Jun 23, 2015·Reproductive Biomedicine Online·Elisabet CluaAnna Veiga
Jul 6, 2011·European Journal of Obstetrics, Gynecology, and Reproductive Biology·Francisca MartínezBuenaventura Coroleu
Dec 24, 2019·Human Reproduction Update·Yossi MizrachiAriel Weissman
Aug 30, 2019·Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology·Elisabet CluaAnna Veiga
Jul 13, 2007·Current Opinion in Obstetrics & Gynecology

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