A prospective trial of adjuvant therapy for high-risk uveal melanoma: assessing 5-year survival outcomes

The British Journal of Ophthalmology
Elaine BinkleyArun D Singh

Abstract

Survival after diagnosis of metastasis from uveal melanoma is poor. Identifying individuals at high risk for metastasis and developing adjuvant therapy to prevent clinically apparent metastasis could improve survival. We conducted an adjuvant trial of sequential, low-dose dacarbazine (DTIC) and interferon-alpha-2b (IFN-α-2b) in patients with cytogenetic high-risk uveal melanoma. Patients diagnosed with iris, ciliary body or choroidal melanoma with high-risk tumour cytogenetics (monosomy 3) were offered adjuvant treatment with low-dose DTIC and IFN-α-2b following primary therapy. Eligible but not enrolled patients were observed for comparison. DTIC was administered at 850 mg/m2 intravenously on days 1 and 28. IFN-α-2b was administered at 3 million units three times a week subcutaneously for 24 weeks beginning at week 9. Hepatic imaging was performed prior to adjuvant therapy and then at least every 6 months. Survival data were collected for 5 years after enrolment. 33 patients (22%) were enrolled (treatment group), 29 (19%) were eligible but did not enrol (observation group) and 88 (59%) were not eligible. The 5-year metastasis-free survival (MFS) was 64%±9% for treated and 33%±10% for observed patients (p=0.05). The 5-year over...Continue Reading

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Citations

Oct 2, 2020·International Journal of Molecular Sciences·Laurien E HoutzagersMartine J Jager
Jul 30, 2020·Current Oncology Reports·Shaheer Khan, Richard D Carvajal
Oct 1, 2020·Cancers·Fabiana MalloneAntonietta Moramarco
Jul 31, 2020·International Journal of Molecular Sciences·Pooneh Chokhachi BaradaranBozena Smolkova
Feb 13, 2021·European Journal of Ophthalmology·Sven Holger BaumChristopher Mohr
May 1, 2021·Cancers·Mariarosaria MarsegliaMichela Croce

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