A prospective trial of D-penicillamine in primary biliary cirrhosis

The New England Journal of Medicine
D S MatloffM M Kaplan

Abstract

We evaluated D-penicillamine in the treatment of primary biliary cirrhosis. In a prospective double-blind trial, 26 patients received D-penicillamine (250 mg four times a day), and 26 received an identical placebo. Although the desired urinary excretion of copper was achieved in patients taking D-penicillamine, there was no improvement in survival or symptoms after 28 months. Serum bilirubin and alkaline phosphatase increased equally in both groups. Alanine and aspartate aminotransferases were lower in the D-penicillamine group, but serum albumin was also lower in this group. Liver histology worsened equally in both groups. Major side effects, some appearing more than 24 months after the start of treatment, occurred in 31 per cent of the patients receiving D-penicillamine. Less serious side effects occurred in an additional 46 per cent. We conclude that D-penicillamine at the dosage we used is not effective in the treatment of primary biliary cirrhosis and is associated with a high incidence of serious side effects.

References

Feb 2, 1978·The New England Journal of Medicine·J R WandsK J Isselbacher
Jun 13, 1975·Annals of the New York Academy of Sciences·I A Jaffe
Dec 13, 1972·Nature: New Biology·M E NimniN Gerth
May 1, 1980·The Journal of Clinical Investigation·P E Lipsky, M Ziff
Dec 1, 1958·Journal of Chronic Diseases·S J CUTLER, F EDERER

❮ Previous
Next ❯

Citations

Nov 1, 1983·Digestive Diseases and Sciences·G H EltaM M Kaplan
Jul 1, 1983·The American Journal of Medicine·K B MillerM M Kaplan
Apr 1, 1995·Pharmacology & Therapeutics·R Poupon, R E Poupon
Jan 1, 1989·Baillière's Clinical Gastroenterology·D R Triger
Jun 29, 1985·Lancet·A OlomuE Elias
Jan 1, 1991·Experimental Pathology·Z SchaffJ Major
Jul 8, 1982·The New England Journal of Medicine·T U Hoogenraad, J W Sindram
Apr 5, 1984·The New England Journal of Medicine·N F LaRussoR L MacCarty
Apr 18, 1985·The New England Journal of Medicine·E R DicksonJ T McCall
Apr 18, 1985·The New England Journal of Medicine·S P James
Dec 4, 1986·The New England Journal of Medicine·M M KaplanK A Eagen
Feb 26, 1987·The New England Journal of Medicine·M M Kaplan
May 12, 1994·The New England Journal of Medicine·R E PouponB Balkau
Oct 1, 1983·Annals of the Rheumatic Diseases·J P DelamereK W Walton
Jun 26, 1982·British Medical Journal·D R Triger
Aug 1, 1989·Postgraduate Medical Journal·A K BurroughsK Rolles
Feb 23, 2010·Translational Research : the Journal of Laboratory and Clinical Medicine·Marina G Silveira, Keith D Lindor
May 1, 1983·Journal of the American Academy of Dermatology·P A LuckyS O Thier
Oct 1, 1983·Journal of the American Academy of Dermatology·F C PowellE R Dickson
Apr 2, 2004·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Marshall M KaplanPeter A L Bonis
Nov 1, 1989·Clinical Immunology and Immunopathology·T IkedaJ Takeuchi
Feb 1, 1986·Australian and New Zealand Journal of Medicine·M MackinnonR A Smallwood
Jan 1, 1992·Journal of Hepatology·R Beukers, S W Schalm
Nov 25, 2004·Clinics in Liver Disease·P Angulo, K D Lindor
Aug 1, 1987·Journal of Hepatology·S Ritland, J Aaseth
Nov 5, 2003·Clinics in Liver Disease·Robert L Carithers
Sep 8, 2000·Baillière's Best Practice & Research. Clinical Gastroenterology·R Poupon, R E Poupon
Jan 15, 1985·American Journal of Ophthalmology·M O'KeefeA Smith
Mar 30, 2017·The Cochrane Database of Systematic Reviews·Francesca SaffiotiDouglas Thorburn
Oct 1, 1989·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·H C MitchisonO F James
Nov 1, 1985·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·H C BodenheimerJ Pezzullo
May 1, 1988·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·R H WiesnerE R Dickson
Mar 1, 1985·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·A NybergR Hällgren
Jan 1, 1988·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·M E GershwinI R Mackay
Nov 1, 1986·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·R J SokolW F Balistreri
Apr 23, 2005·The Cochrane Database of Systematic Reviews·M PrinceC Gluud

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.