A prospective trial of preoperative chemotherapy in resectable breast cancer: predictors of breast-conservation therapy feasibility

Annals of Surgical Oncology
Lisa A NewmanKelly K Hunt

Abstract

The role of preoperative chemotherapy for breast cancer is evolving. We initiated a prospective trial of sequential preoperative paclitaxel and doxorubicin-based combination chemotherapy in patients with stage I (tumor >1 cm), II, or IIIA disease and evaluated its effect on breast-conservation therapy (BCT) eligibility. Pathology findings for the initial 100 consecutive patients who underwent surgery were analyzed. The median tumor size at presentation was 2.4 cm, and 39% of patients were deemed eligible for BCT. After chemotherapy, the median tumor size decreased to 1.0 cm (P <.001), and 59% of patients seemed BCT eligible (BCT conversion rate 34% among patients initially assessed as BCT ineligible; P <.001). Final pathology confirmed BCT feasibility in 90% of patients assessed as BCT candidates before surgery. The pathology from mastectomy specimens revealed BCT feasibility in 11 (27%) of 41 patients deemed BCT ineligible. Multivariate analysis revealed lobular histology, multicentricity, and calcifications, but not age, initial tumor size, or nodal status to predict final pathology indicating BCT ineligibility. Induction chemotherapy improves BCT eligibility for breast cancer patients. Improved breast imaging methods after c...Continue Reading

References

May 1, 1991·Annals of Oncology : Official Journal of the European Society for Medical Oncology·L MauriacJ M Dilhuydy
Oct 3, 1990·Journal of the National Cancer Institute·G BonadonnaF Rilke
Mar 1, 1995·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·T J PowlesD Cosgrove
Sep 1, 1994·Annals of Oncology : Official Journal of the European Society for Medical Oncology·V F SemiglazovO F Chepic
Jan 1, 1994·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·S M SchollP Beuzeboc
Nov 1, 1995·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·S M SchollJ C Durand
Apr 1, 1996·The Surgical Clinics of North America·K K HuntG N Hortobagyi
Jan 1, 1996·Clinical Oncology : a Journal of the Royal College of Radiologists·N G DavidsonY T Chan
Jul 1, 1997·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·B FisherN V Dimitrov
Aug 15, 1998·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·B FisherH D Bear
Dec 23, 1998·Annals of Oncology : Official Journal of the European Society for Medical Oncology·A MakrisH T Ford
Mar 18, 1999·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·H M KuererS E Singletary
Nov 5, 1999·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·A U BuzdarG N Hortobagyi
Mar 29, 2000·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·A C Wolff, N E Davidson
Oct 14, 2000·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·N AvrilM Schwaiger

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Citations

Jun 3, 2014·Surgical Oncology Clinics of North America·Mediget Teshome, Kelly K Hunt
May 31, 2006·European Radiology·Anne A TardivonFabienne Thibault
Sep 20, 2006·Annals of Surgical Oncology·Sibylle LoiblManfred Kaufmann
Oct 23, 2014·Indian Journal of Medical and Paediatric Oncology : Official Journal of Indian Society of Medical & Paediatric Oncology·Tapesh BhattacharyyaGurpreet Singh
Aug 27, 2011·Breast Cancer Research and Treatment·J Michael DixonJeremy Thomas
Sep 24, 2004·AJR. American Journal of Roentgenology·Fabienne ThibaultUNKNOWN Institut Curie Breast Cancer Group
Mar 7, 2006·Breast Cancer : the Journal of the Japanese Breast Cancer Society·Katsumasa KuroiFutoshi Akiyama
Jan 10, 2009·Annals of Surgical Oncology·Carla J ChristyDonald R Lannin
Mar 13, 2009·Annals of Surgical Oncology·Judy C BougheyIsabelle Bedrosian
Jul 12, 2011·Annals of Surgical Oncology·Florian FitzalMichael Gnant
Jun 6, 2003·Journal of the American College of Surgeons·David M Ota
Dec 11, 2003·Current Oncology Reports·Lisa A Newman
May 27, 2008·Journal of the American College of Surgeons·Geneviève SoucyPierre Dubé
May 15, 2007·The Surgical Clinics of North America·Marie Catherine Lee, Lisa A Newman
May 15, 2007·The Surgical Clinics of North America·Jennifer F Waljee, Lisa A Newman
Mar 3, 2006·The Breast Journal·Sushil BeriwalJorge A Garcia-Young
Jul 25, 2006·Current Problems in Surgery·Christopher A GarcesWilliam G Cance
Jul 24, 2003·The Surgical Clinics of North America·Lisa A Newman, Tara A Washington
Jul 5, 2015·European Journal of Surgical Oncology : the Journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology·H KaranlikA Aydiner
Mar 3, 2015·Annals of Surgical Oncology·Eleftherios P Mamounas
Aug 4, 2012·International Journal of Surgery·Angelo Gustavo Zucca MatthesRene Aloísio da Costa Viera
Mar 18, 2017·Scientific Reports·Denggang FuBrian Z Ring
Oct 28, 2019·Cancers·Mohammad Khusni B Ahmat AminHisakazu Ogita
Mar 10, 2005·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Lisa A Newman, Henry M Kuerer
May 4, 2005·Annals of Surgical Oncology·Siegal SadetzkiMoshe Z Papa
Sep 13, 2005·Breast Cancer Research and Treatment·Anne F SchottLaurence H Baker
Aug 11, 2007·Biomedical Papers of the Medical Faculty of the University Palacký, Olomouc, Czechoslovakia·Gulisa TurashviliZdenek Kolar
Jul 29, 2015·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Otto Metzger FilhoAron Goldhirsch
Feb 16, 2005·Current Opinion in Obstetrics & Gynecology·Veronique Cocquyt, Simon Van Belle

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