PMID: 2500137Apr 1, 1989Paper

A prospective trial of prophylactic intravenous immune globulin for the prevention of infections in severely burned patients

Burns : Journal of the International Society for Burn Injuries
J P WaymackR G Kopcha

Abstract

A prospective randomized double-blind study evaluated the efficacy of i.v. immune globulin in preventing infectious complications in severely burned patients. Fifty patients were randomized to receive either i.v. immune globulin or placebo. Each group of patients was treated with twice weekly infusions for either 5 weeks or until the patients' wounds were covered. Patients treated with the immune globulin had an immediate correction of their depressed serum IgG levels, however there was no change in the infection or mortality rates. No adverse effects were noted with the immune globulin treatments. One potential weakness of this study was the greater burn surface area and a higher incidence of inhalation injury in adult patients treated with i.v. immune globulin compared to controls.

References

Jul 1, 1986·Reviews of Infectious Diseases·J P McCueR Tenold
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Dec 1, 1970·Annals of Surgery·A M MunsterB A Pruitt
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Citations

Nov 9, 2006·Journal of Burn Care & Research : Official Publication of the American Burn Association·Jefferson M LyonsRichard Kagan
May 1, 1994·Pediatric Allergy and Immunology : Official Publication of the European Society of Pediatric Allergy and Immunology·R I Schiff
May 31, 1994·Annals of the New York Academy of Sciences·J P Waymack, R L Rutan
Nov 1, 1994·Intensive Care Medicine·L Donati, P Periti
Mar 24, 2016·Biomolecules·Ana Filipa Barahona Afonso, Cristina Maria Pires João
Mar 1, 1992·Critical Reviews in Oncology/hematology·K P DunsmoreJ Kurtzberg
Dec 1, 1990·Burns : Journal of the International Society for Burn Injuries·J D FrameM E Hackett

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