A Prospective, Ultrasound-Based Study to Evaluate Risk Factors for Uterine Fibroid Incidence and Growth: Methods and Results of Recruitment

Journal of Women's Health
Donna Day BairdGanesa Wegienka

Abstract

Uterine fibroids are common, benign, smooth-muscle tumors that can cause major morbidity for reproductive-age women, often requiring invasive treatment. Despite this personal and public health burden, no prior study has attempted to periodically screen fibroid-free women with ultrasound to detect incident disease and identify risk factors. We designed a study to prospectively investigate development of fibroids by enrolling women without a clinical diagnosis of fibroids and screening for fibroids with ultrasound at baseline. Enrollment procedures included extensive questionnaires and specimen collection (blood, urine, vaginal swabs). The cohort is followed at approximately 20-month intervals. At each follow-up there are updates to the questionnaire data, further specimen collection, and an ultrasound examination. We identify incident disease and measure tumor growth. The two exposures of primary interest are vitamin D insufficiency and reproductive tract infections. This manuscript provides a detailed description of the study methods, recruitment results, and participant characteristics. The Study of Environment, Lifestyle and Fibroids enrolled 1,696 African American women aged 23-34 years. "Family and friends" was a leading re...Continue Reading

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Citations

Jul 16, 2016·American Journal of Obstetrics and Gynecology·Leah Hawkins BresslerErica E Marsh
Aug 25, 2016·Fertility and Sterility·Tiffany A KatzAyman Al-Hendy
Jan 15, 2019·Journal of Women's Health·Kristen UpsonDonna D Baird
Aug 5, 2016·The Journal of Clinical Endocrinology and Metabolism·Quaker E HarmonDonna D Baird
Sep 6, 2020·Journal of Racial and Ethnic Health Disparities·Kristen R MooreDonna D Baird
Jun 20, 2020·American Journal of Epidemiology·Theodore M BraskyLauren A Wise
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Sep 28, 2020·Journal of Exposure Science & Environmental Epidemiology·Amelia K WesselinkLauren A Wise
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Nov 28, 2018·BMC Medical Research Methodology·Samantha TeagueUNKNOWN SEED Lifecourse Sciences Theme
Jan 30, 2019·Journal of Exposure Science & Environmental Epidemiology·Traci N BetheaLauren A Wise
Feb 28, 2020·Obstetrical & Gynecological Survey·Salvatore Giovanni VitaleAntonio Cianci
Nov 10, 2018·Human Reproduction·Kristen UpsonDonna D Baird
Oct 28, 2020·Reproductive Sciences·Michał CiebieraAyman Al-Hendy
Dec 17, 2020·International Journal of Environmental Research and Public Health·Symielle A GastonChandra L Jackson
Nov 19, 2020·Environmental Health Perspectives·Kristen UpsonDonna D Baird
Sep 10, 2020·Biology of Reproduction·Sneh M Toprani, Varsha Kelkar Mane
Mar 6, 2021·Journal of Women's Health·Maya A WrightHelen B Chin
Jul 10, 2019·International Journal of Hygiene and Environmental Health·Amelia K WesselinkLauren A Wise
Mar 24, 2021·Fertility and Sterility·Lia A BernardiErica E Marsh
Dec 23, 2020·Journal of the Academy of Nutrition and Dietetics·Lauren A WiseDonna D Baird
May 12, 2021·American Journal of Obstetrics and Gynecology·Emma C ManuelErica E Marsh
Sep 15, 2021·Journal of Women's Health·Helen B ChinDonna D Baird
Oct 1, 2021·Environmental Science & Technology·Samantha SchildrothBirgit Claus Henn

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Methods Mentioned

BETA
hysterectomy
medical procedure
blood draw
contraception

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