A prospectively measured serum biomarker for a tobacco-specific carcinogen and lung cancer in smokers

Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology
Timothy R ChurchStephen S Hecht

Abstract

No prior studies have related a tobacco-specific carcinogen to the risk of lung cancer in smokers. Of the over 60 known carcinogens in cigarette smoke, 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) is specific to tobacco and causes lung cancer in laboratory animals. Its metabolites, 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol and its glucuronides (total NNAL), have been studied as biomarkers of exposure to NNK. We studied the relation of prospectively measured NNK biomarkers to lung cancer risk. In a case-control study nested in the Prostate, Lung, Colorectal, and Ovarian Cancer Screening Trial, we randomly selected 100 lung cancer cases and 100 controls who smoked at baseline and analyzed their baseline serum for total NNAL, cotinine, and r-1,t-2,3,c-4-tetrahydroxy-1,2,3,4-tetrahydrophenanthrene (PheT), a biomarker of polycyclic aromatic hydrocarbon exposure and metabolic activation. To examine the association of the biomarkers with all lung cancers and for histologic subtypes, we computed odds ratios for total NNAL, PheT, and cotinine using logistic regression to adjust for potential confounders. Individual associations of age, smoking duration, and total NNAL with lung cancer risk were statistically significant. Aft...Continue Reading

References

Jun 24, 1998·Chemical Research in Toxicology·S S Hecht
Jan 15, 1999·Epidemiology·S GreenlandJ M Robins
Feb 24, 2001·Controlled Clinical Trials·J K GohaganUNKNOWN Prostate, Lung, Colorectal and Ovarian Cancer Screening Trial Project Team
Oct 16, 2002·Oncogene·John K Wiencke
Oct 23, 2003·Nature Reviews. Cancer·Stephen S Hecht
Mar 16, 2005·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Jee Young KimDavid C Christiani
Dec 21, 2005·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Stephen S HechtSteven G Carmella
May 17, 2006·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Stephen S HechtDeborah J Hennrikus
Jun 16, 2006·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Paolo BoffettaAage Andersen
Aug 10, 2006·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Steven G CarmellaStephen S Hecht
Aug 22, 2006·Nicotine & Tobacco Research : Official Journal of the Society for Research on Nicotine and Tobacco·Dorothy K HatsukamiStephen S Hecht
Oct 13, 2006·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Stephen S HechtDorothy K Hatsukami
Dec 14, 2006·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Dorothy K HatsukamiStephen S Hecht
Feb 3, 2007·Pharmacology, Biochemistry, and Behavior·Dorothy HatsukamiStephen Hecht
Jul 24, 2007·Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences·Sharon E MurphyLinda B von Weymarn
Aug 9, 2007·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Stephen S HechtDorothy K Hatsukami
Aug 30, 2008·Nicotine & Tobacco Research : Official Journal of the Society for Research on Nicotine and Tobacco·Dorothy K HatsukamiStephen S Hecht

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Citations

Oct 23, 2010·Cancer Causes & Control : CCC·David M BurnsNigel Gray
Apr 23, 2010·Chemical Research in Toxicology·Stephen S HechtDorothy Hatsukami
Jun 25, 2009·Nature Reviews. Cancer·Stephen S HechtDorothy K Hatsukami
Mar 4, 2011·American Journal of Epidemiology·Wael K Al-Delaimy, Walter C Willett
May 25, 2011·Journal of the National Cancer Institute·C Martin TammemagiPhilip C Prorok
Apr 27, 2012·Journal of the National Cancer Institute·Margaret R SpitzNeil E Caporaso
Feb 18, 2011·Nicotine & Tobacco Research : Official Journal of the Society for Research on Nicotine and Tobacco·Stephen S Hecht
May 7, 2011·Nicotine & Tobacco Research : Official Journal of the Society for Research on Nicotine and Tobacco·Neal L BenowitzPeyton Jacob
Jan 20, 2012·Nicotine & Tobacco Research : Official Journal of the Society for Research on Nicotine and Tobacco·Irina StepanovDorothy K Hatsukami
Jun 8, 2012·International Journal of Endocrinology·Gregory E RiceMurray D Mitchell
Dec 5, 2009·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Dorothy K HatsukamiPeter G Shields
Dec 5, 2009·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Maciej L GoniewiczNeal L Benowitz
Dec 5, 2009·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·John L PaulyPeter G Shields
Dec 20, 2012·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Miranda R JonesAna Navas-Acien
Sep 26, 2013·International Journal of Environmental Research and Public Health·Clement Kleinstreuer, Yu Feng
Mar 22, 2014·Carcinogenesis·Amanda J CrossSteven C Moore
Feb 2, 2013·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Andy Z X ZhuRachel F Tyndale
Jun 13, 2012·Cellular and Molecular Life Sciences : CMLS·Lei ZhangDavid T W Wong
Mar 10, 2010·Critical Reviews in Toxicology·Kumar A Shah, H Thomas Karnes
Jan 23, 2013·Biomarkers : Biochemical Indicators of Exposure, Response, and Susceptibility to Chemicals·Stephen S HechtDorothy K Hatsukami
Aug 2, 2013·Biomarkers : Biochemical Indicators of Exposure, Response, and Susceptibility to Chemicals·Evan O GreggMichael McEwan
Apr 9, 2010·Biomarkers : Biochemical Indicators of Exposure, Response, and Susceptibility to Chemicals·Timothy R ChurchStephen S Hecht
Dec 19, 2015·Accounts of Chemical Research·Stephen S HechtSteven G Carmella
Jan 24, 2012·Mutation Research·Philip A J CrosbieAndrew C Povey
Jul 15, 2009·International Journal of Cancer. Journal International Du Cancer·Kiersten S DerbyLoïc Le Marchand
Sep 5, 2012·International Journal of Cancer. Journal International Du Cancer·Stephen S Hecht
Nov 19, 2013·International Journal of Cancer. Journal International Du Cancer·Irina StepanovJian-Min Yuan
Nov 26, 2013·Mass Spectrometry Reviews·Graziano ColomboIsabella Dalle-Donne
Nov 17, 2015·American Journal of Epidemiology·Hansong WangLoïc Le Marchand
Sep 18, 2015·Frontiers in Oncology·Tore Sanner, Tom K Grimsrud
Dec 8, 2014·Nicotine & Tobacco Research : Official Journal of the Society for Research on Nicotine and Tobacco·Christine D Czoli, David Hammond

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