Abstract
The apolipoprotein E (ApoE) e4 allele has been associated with an increased risk for Alzheimer's disease, whereas the e2 allele has been shown to be protective. Similar effects in Down's syndrome (DS) have been postulated but not yet demonstrated. We obtained DNA from 221 DS individuals and from 162 population controls, and 77 DS children. Older DS subjects were evaluated for dementia and compared to age-matched DS controls. The DS sample with dementia (n = 31) had a significantly lower frequency of the ApoE e2 allele compared to age-matched nondemented DS controls (0% vs. 8.3%, p = .0136). The older DS population had a significantly lower frequency of ApoE e4 compared to population controls (11.7% vs. 20.6%, chi-square 8.9, p = .0028). The lower frequency of the e2 allele in demented DS subjects compared to age-matched nondemented DS controls suggests a protective effect for ApoE e2 in the development of dementia in DS. The lower frequency of ApoE e4 in our older DS sample compared to population controls points to a detrimental effect of the e4 allele on longevity.
References
Mar 1, 1990·Archives of Neurology·H M Evenhuis
Aug 1, 1988·Histopathology·D M Mann
Jul 1, 1985·Neurology·K E WisniewskiH M Wisniewski
Aug 1, 1995·Annals of Neurology·W A van GoolC M van Duijn
Dec 20, 1994·Neuroreport·M C RoystonR Crook
Jan 1, 1995·Annals of Neurology·T WisniewskiB Frangione
Apr 16, 1994·Lancet·J HardyG Roberts
Jun 4, 1994·Lancet·C TalbotA Goate
Nov 3, 1994·Nature·J MaH Potter
Sep 18, 1993·Lancet·J PoirierS Gauthier
Jan 1, 1994·Nature Genetics·F SchächterD Cohen
Aug 1, 1993·Neurology·A M SaundersM J Alberts
Mar 1, 1993·Proceedings of the National Academy of Sciences of the United States of America·W J StrittmatterA D Roses
Oct 15, 1996·Biological Psychiatry·M CosgraveM Gill
Nov 1, 1996·Annals of Neurology·N SchupfR Mayeux
Citations
Jul 19, 2000·Mental Retardation and Developmental Disabilities Research Reviews·R S Chapman, L J Hesketh
Jan 6, 2000·Journal of Intellectual Disability Research : JIDR·M P CosgraveB A Lawlor
Jun 27, 2008·Intellectual and Developmental Disabilities·Sharon J Krinsky-McHaleWayne Silverman
Jan 21, 2014·BMC Research Notes·Ashok PatelVee P Prasher
Nov 13, 2002·Journal of Intellectual Disability Research : JIDR·M McCarronC Beagly
Sep 12, 2006·Journal of Intellectual Disability Research : JIDR·A CoppusC van Duijin
Aug 27, 2005·Neuroscience Letters·Warren B ZigmanWayne Silverman
Dec 19, 2001·International Journal of Geriatric Psychiatry·J TyrrellB A Lawlor
Oct 31, 2002·Human Psychopharmacology·Kurt Heininger
Jun 22, 2000·American Journal of Medical Genetics·S MoalemA C Warren
Oct 2, 2012·American Journal of Medical Genetics. Part a·Rao FuForbes D Porter
Mar 27, 2001·Journal of Developmental and Behavioral Pediatrics : JDBP·G T Capone
May 2, 2002·The British Journal of Psychiatry : the Journal of Mental Science·Nicole Schupf, Gertrude H Sergievsky
Jul 27, 2000·The British Journal of Psychiatry : the Journal of Mental Science·S DebM J Owen
Dec 3, 1999·American Journal of Medical Genetics·J TyrrellM Gill
Oct 1, 2020·Alzheimer's & Dementia : Diagnosis, Assessment & Disease Monitoring·Florence LaiH Diana Rosas
Nov 6, 2020·Molecular Neurodegeneration·Zonghua LiGuojun Bu
Jan 1, 2020·International Journal of Developmental Disabilities·Maire E Percy, Walter J Lukiw