A protein encoded by the herpes simplex virus (HSV) type 1 2-kilobase latency-associated transcript is phosphorylated, localized to the nucleus, and overcomes the repression of expression from exogenous promoters when inserted into the quiescent HSV genome

Journal of Virology
S K ThomasR S Coffin

Abstract

Herpes simplex virus (HSV) is characterized by its ability to establish a latent infection in sensory neurons, from which it can periodically reactivate. The mechanisms of latency, however, remain unclear. The HSV genome is quiescent during latency except for the expression of the latency-associated transcripts (LATs). Although the exact function of the LATs remains obscure, current evidence suggests they are multifunctional and are involved in both establishment of latency and reactivation from latency. The LATs contain several open reading frames (ORFs). One or more of the functions of the LATs could therefore be protein mediated. We have previously reported that deregulated expression of the largest of the HSV type 1 (HSV-1) LAT ORFs ( approximately 274 amino acids) greatly enhances virus growth in cell types that are normally relatively nonpermissive for HSV replication and also that it complements mutations to the immediate-early (IE) gene ICP0 (S. K. Thomas, G. Gough, D. S. Latchman, and R. S. Coffin, J. Virol. 73:6618-6625, 1999). Here we show that LAT ORF expression overcomes the repression of expression from exogenous promoters introduced into the HSV-1 genome which normally occurs in the absence of IE gene expression....Continue Reading

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Citations

Sep 5, 2002·Reviews in Medical Virology·Peter G E Kennedy
Jun 14, 2005·Virus Research·S Efstathiou, C M Preston
Dec 3, 2002·Current Opinion in Biotechnology·Edward A BurtonJoseph C Glorioso
Jan 15, 2003·Clinical Microbiology Reviews·Clinton Jones
Feb 20, 2010·Interdisciplinary Perspectives on Infectious Diseases·Guey-Chuen Perng, Clinton Jones
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Feb 3, 2006·Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases·A Kolokotronis, S Doumas
Feb 1, 2008·ORL; Journal for Oto-rhino-laryngology and Its Related Specialties·I Pyykko, J Zou
May 3, 2003·Nature Reviews. Genetics·Clare E ThomasMark A Kay
Jun 28, 2008·Seminars in Ophthalmology·Hassanain S TomaJames M Hill

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