A protein G-related cell surface protein in Streptococcus zooepidemicus.

Infection and Immunity
H JonssonBengt Guss

Abstract

This work describes the cloning and sequencing of a gene encoding a plasma protein receptor from Streptococcus zooepidemicus. This receptor, termed protein ZAG, is a 45-kDa protein that binds alpha 2-macroglobulin (alpha 2M), serum albumin, and immunoglobulin G (IgG). The IgG-binding activity is located in the C-terminal part of the molecule and is mediated by two repeated domains highly homologous to each other as well as to the corresponding domains in streptococcal type III Fc receptors. The IgG-binding profile of protein ZAG is similar to that previously reported for S. zooepidemicus. Binding to serum albumin is mediated by a short amino acid sequence in the middle of the molecule. This domain shows homology to previously described albumin-binding proteins from streptococci, and the albumin-binding profile of protein ZAG is similar to that of streptococcal protein G. The N-terminal part of protein ZAG, which mediates binding to the plasma proteinase inhibitor alpha 2M, is composed of a unique stretch of amino acids. Protein ZAG competes for the same, or nearby, binding site(s) in alpha 2M as do two recently described Streptococcus dysgalactiae receptors, although the sequences of the alpha 2M-binding domains in these three ...Continue Reading

References

Aug 1, 1979·The Biochemical Journal·A J BarrettC A Sayers
Aug 1, 1992·The Journal of Dairy Research·L K Rantamäki, H P Müller
Sep 15, 1992·Proceedings of the National Academy of Sciences of the United States of America·I M FrickL Björck
Jul 24, 1992·Cell·O SchneewindV A Fischetti
Aug 1, 1990·FEMS Microbiology Letters·P Valentin-WeigandG S Chhatwal
Oct 1, 1991·International Journal of Systematic Bacteriology·R W BentleyM D Collins
Mar 1, 1991·Reviews of Infectious Diseases·S F BradleyC A Kauffman
Oct 5, 1990·European Journal of Biochemistry·P A NygrenM Uhlén
Apr 1, 1988·Journal of Molecular Recognition : JMR·P A NygrenE Palmcrantz
Oct 15, 1987·European Journal of Biochemistry·A OlssonM Uhlén
Nov 1, 1993·Veterinary Microbiology·J F Timoney, M M Mukhtar
Mar 15, 1994·European Journal of Biochemistry·H Jonsson, H P Müller

❮ Previous
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Citations

Oct 25, 1996·The Journal of Biological Chemistry·M de ChâteauL Björck
Jan 1, 1997·Critical Reviews in Oral Biology and Medicine : an Official Publication of the American Association of Oral Biologists·H F Jenkinson, R J Lamont
Jun 24, 2015·Journal of Feline Medicine and Surgery·Tadeusz FrymusUNKNOWN European Advisory Board on Cat Diseases
Dec 1, 2005·Applied Microbiology and Biotechnology·Emily M CoyleMichael D P Boyle
Dec 22, 1999·Infection and Immunity·J VasiB Guss
May 17, 2011·Biochemistry. Biokhimii︠a︡·E V Sidorin, T F Solov'eva
Jul 12, 2008·FEMS Microbiology Letters·Ying MaoChengping Lu
May 22, 2003·FEMS Microbiology Letters·Jonas LannergårdBengt Guss
Dec 7, 2018·Journal of Chromatography. a·Raquel Dos SantosA Cecília A Roque
Mar 14, 1997·Journal of Molecular Biology·M U JohanssonL Björck
Mar 6, 1999·Microbiology and Molecular Biology Reviews : MMBR·W W Navarre, O Schneewind
Aug 3, 2019·Microbiology Spectrum·Vincent A Fischetti
Mar 16, 2019·Microbiology Spectrum·Horst Malke
May 22, 2019·Microbiology Spectrum·Claire E TurnerAndroulla Efstratiou
Oct 1, 1996·Infection and Immunity·H LindmarkB Guss
Mar 31, 2009·Proteome Science·Esteban MarcellinLars K Nielsen

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