PMID: 2112550Jun 1, 1990Paper

A protein homologous to the Torpedo postsynaptic 58K protein is present at the myotendinous junction

The Journal of Cell Biology
Q ChenH B Peng

Abstract

The 58K protein is a peripheral membrane protein enriched in the acetylcholine receptor (AChR)-rich postsynaptic membrane of Torpedo electric organ. Because of its coexistence with AChRs in the postsynaptic membrane in both electrocytes and skeletal muscle, it is thought to be involved in the formation and maintenance of AChR clusters. Using an mAb against the 58K protein of Torpedo electric organ, we have identified a single protein band in SDS-PAGE analysis of Xenopus myotomal muscle with an apparent molecular mass of 48 kD. With this antibody, the distribution of this protein was examined in the myotomal muscle fibers with immunofluorescence techniques. We found that the 48K protein is concentrated at the myotendinous junctions (MTJs) of these muscle fibers. The MTJ is also enriched in talin and vinculin. By double labeling muscle fibers with antibodies against talin and the 48K protein, these two proteins were found to colocalize at the membrane invaginations of the MTJ. In cultured myotomal muscle cells, the 48K protein and talin are also colocalized at sites of membrane-myofibril interaction. The 48K protein is, however, not found at focal adhesion sites in nonmuscle cells, which are enriched in talin. These data suggest ...Continue Reading

References

Jan 1, 1978·Proceedings of the National Academy of Sciences of the United States of America·H B Peng, Y Nakajima
Sep 1, 1979·Proceedings of the National Academy of Sciences of the United States of America·H TowbinJ Gordon
Jan 1, 1989·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·P W Luther, R J Bloch
Jul 1, 1989·Experimental Cell Research·D BozyczkoA F Horwitz
Mar 1, 1986·Experimental Cell Research·R SealockK Burridge
Oct 1, 1986·The Journal of Cell Biology·J G TidballK Burridge
Sep 1, 1988·The Journal of Cell Biology·L S MusilJ P Merlie
Jan 1, 1986·Cell and Tissue Research·J G Tidball, T L Daniel
Dec 1, 1985·Proceedings of the National Academy of Sciences of the United States of America·S J Burden
Apr 1, 1986·The Journal of Cell Biology·R J Bloch
May 21, 1966·Nature·R Miledi, J Zelená
Jan 1, 1982·Annual Review of Neuroscience·J Massoulié, S Bon
Jan 1, 1983·Cell Motility·J A TrotterA Samora
Oct 1, 1981·The Anatomical Record·J A TrotterB P Avner

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Citations

Jan 1, 1991·Neuromuscular Disorders : NMD·T S KhuranaL M Kunkel
Sep 23, 2003·Journal of Molecular Biology·Karine GrisoniLaurent Ségalat
Sep 20, 2000·The Journal of Cell Biology·Z DaiH B Peng
Sep 15, 1992·European Journal of Biochemistry·J V SmallL E Thornell
Apr 17, 2004·Traffic·Mhairi C TowlerFrances M Brodsky
Nov 14, 2008·The Journal of Comparative Neurology·Evdokia Menelaou, Kurt R Svoboda
Jul 30, 2014·Developmental Biology·Yina ZhangStephan Kröger
Nov 8, 2014·The European Journal of Neuroscience·Yina ZhangStephan Kröger
Mar 29, 2000·Molecular and Cellular Neurosciences·N R Kramarcy, R Sealock
Mar 15, 2013·American Journal of Physiology. Cell Physiology·Han-Zhong FengJ-P Jin

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