PMID: 4905993Nov 1, 1969Paper

A protein inhibitor of acid deoxyribonucleases

Proceedings of the National Academy of Sciences of the United States of America
P Lesca, C Paoletti

Abstract

A protein extracted and partially purified (about 100-fold) from mouse liver is able to inhibit the acid DNases from different tissues and species, whereas pancreatic DNase and E. coli endonuclease I are not inhibited. The acid DNase displays typical Michaelis-Menten kinetics in the absence of this inhibitor, but the kinetics become sigmoidal in its presence. The existence of a DNase-inhibitor complex is demonstrated by physicochemical experiments. Moreover, the inhibitor is able to reactivate the DNase treated by urea, probably through a reassociation of the inactive monomers to a dimeric state. An allosteric model in which the DNase-inhibitor complex is composed of catalytic (DNase) and regulatory (inhibitor) subunits could explain these data.

Citations

Apr 17, 1978·Molecular & General Genetics : MGG·K Hasunuma
May 30, 2002·Biochemical Pharmacology·James M JamisonJack L Summers
Nov 1, 1970·Proceedings of the National Academy of Sciences of the United States of America·J P ChangeuxC Y Lee
Feb 1, 1971·European Journal of Biochemistry·T Lindahl
Mar 29, 2001·Experimental Eye Research·A TorrigliaM F Counis
Jul 22, 2014·European Journal of Medicinal Chemistry·Ana KolarevicAndrija Smelcerovic
Jan 24, 2006·Comparative Biochemistry and Physiology. Part B, Biochemistry & Molecular Biology·Kersti Øverbø, Bjørnar Myrnes
Dec 19, 2000·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·H S TaperJ L Summers
Jan 1, 1974·Angewandte Chemie·H Tschesche
Mar 1, 1980·Archives of Andrology·J Fisher, B Bartoov

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society
H S Taper
The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society
K F Swingle, L J Cole
© 2021 Meta ULC. All rights reserved