PMID: 2508086DOI: 10.1002/prot.340050405Jan 1, 1989Paper
A protein structural motif that bends DNA
Proteins
S W WhiteI Tanaka
Abstract
The prokaryotic protein HU, integration host factor (IHF) from Escherichia coli, and transcription factor 1 (TF1) from bacteriophage SPO1 are closely related molecules. Biochemical results suggest that the role of these proteins is to bind and bend DNA. From the high-resolution structure of HU, we propose a model for this interaction with DNA. Crucial amino acid differences between the proteins can be rationalized in terms of their different specific functions.
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