A protein@metal-organic framework nanocomposite for pH-triggered anticancer drug delivery

Dalton Transactions : an International Journal of Inorganic Chemistry
Zuozhong LiangHaoquan Zheng

Abstract

We have synthesized a core@shell nanocomposite using biocompatible bovine serum albumin (BSA) as the core and a pH-sensitive metal-organic framework (MOF) as the shell. Doxorubicin (DOX)/BSA nanoparticles as cores have been prepared. A zeolitic imidazolate framework-8 (ZIF-8) layer has been coated on the outer surface of the DOX/BSA core. The ZIF layer acts as a capsule for the safe storage of DOX under physiological conditions. An efficient pH-responsive drug delivery system using a BSA/DOX@ZIF, in which the drug is not released in PBS at pH 7.4 but is released at low pH (5.0-6.0), has been constructed. Compared to the pure ZIF, a better biocompatibility has been obtained using the BSA/DOX@ZIF. The BSA/DOX@ZIF shows a much higher efficacy than free DOX against the breast cancer cell line MCF-7. The positive charges on the outer surface of the BSA/DOX@ZIF also improve its cellular uptake.

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Citations

May 12, 2020·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Mark Q TolentinoJessica L Rouge
Apr 25, 2020·Biotechnology Journal·Johannes W M Osterrieth, David Fairen-Jimenez
Jan 31, 2020·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Xinwei FuChao Yu
Aug 17, 2020·Scientific Reports·Ryo AraiHiroshi Nishihara
Mar 19, 2019·Journal of Biomaterials Applications·Chong ChengYi Lv
Dec 8, 2020·Chemical Society Reviews·Jintong LiuJianping Lei
Feb 7, 2021·Materials Science & Engineering. C, Materials for Biological Applications·Özge ToprakAyşe Karakeçili
Feb 7, 2021·Materials Science & Engineering. C, Materials for Biological Applications·Rajeshkumar AnbazhaganHsieh-Chih Tsai
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Nov 18, 2021·Advanced Healthcare Materials·He DingPiaoping Yang

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Methods Mentioned

BETA
X-ray
scanning
transmission electron microscopy
dynamic light scattering
scanning electron microscopy

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