PMID: 3749258Jul 1, 1986Paper

A proton NMR relaxation evaluation of a model of brain oedema fluid

Physics in Medicine and Biology
P S AllenD P Boisvert

Abstract

Using CSF/protein solutions as models of vasogenic extracellular fluid, the concentration dependences of longitudinal and transverse proton relaxation rates have been measured at 37 degrees C and 100 MHz for the serum proteins, albumin, IgG, a 2.8:1 mixture of albumin and IgG and human serum itself. These measurements have been used to determine the sensitivity of proton relaxation rates to the amount and the type of the protein in oedema fluid, and to establish the significance of both of these factors in relation to a separation of vasogenic from cytotoxic oedema. An extension of the two-environment rapid-exchange model of solvent relaxation is presented, which accounts for the measurements on protein mixtures and which enables estimates to be made of the number and the transverse relaxation rate of water protons associated with the protein surface.

References

Nov 26, 1976·Biochimica Et Biophysica Acta·L Grösch, F Noack
Jan 1, 1974·Annual Review of Biophysics and Bioengineering·R Cooke, I D Kuntz
Jul 4, 1974·Biochimica Et Biophysica Acta·P S Belton, K J Packer
Jan 1, 1967·Journal of Neuropathology and Experimental Neurology·I Klatzo
Jun 1, 1982·Journal of Neurosurgery·S NaruseK Yoshizaki
Sep 1, 1984·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Y S KangI M Armitage
Jan 1, 1982·Magnetic Resonance Imaging·G D FullertonN C Dornbluth
Sep 1, 1982·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·K A Hossmann

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Citations

Aug 1, 1991·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·R S MenonP S Allen
Jan 10, 2013·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Deepu R PillaiFelix Schlachetzki
Apr 1, 1988·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·R GrantG Teasdale

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