PMID: 8604676Jan 1, 1996Paper

A psyllium-enriched cereal for the treatment of hypercholesterolemia in children: a controlled, double-blind, crossover study

The American Journal of Clinical Nutrition
M H DavidsonK B Drennan

Abstract

Psyllium, a water-soluble fiber, has been shown to lower total serum and low-density-lipoprotein (LDL)-cholesterol concentrations in adult hypercholesterolemic subjects and may be effective in the treatment of hypercholesterolemia in children. The effects of a psyllium-enriched cereal were compared with a matched control cereal in a double-blind, crossover fashion in 25 children, 6-18 y old, with hypercholesterolemia. After an 8-wk diet-stabilization period, the subjects were randomly assigned to receive the active or control cereals for 6 wk, followed by a 6-wk washout period and a 6-wk crossover treatment period. Whereas no changes were noted in total and LDL-cholesterol concentrations during consumption of the control cereal, significant changes were seen during the psyllium-cereal periods [0.31 mmol/L (12.1 mg/dL) and 0.28 mmol/L (10.9 mg/dL); P = 0.03 and 0.01, respectively]. The psyllium-enriched cereal was well tolerated throughout the trial. Consumption of the psyllium-enriched cereal resulted in a modest 7% reduction in LDL-cholesterol concentrations compared with the control cereal when used in this pediatric hypercholesterolemic sample. Psyllium offers a potential adjunct to a low-fat diet for the treatment of hyperc...Continue Reading

Citations

Jun 12, 2008·Clinical Pediatrics·Saul MillerBrian W McCrindle
Apr 20, 2012·Drugs·Marjet J A M BraamskampAlbert Wiegman
Mar 20, 2013·Pharmaceutical Development and Technology·Waseem KaialyAli Nokhodchi
May 27, 2015·European Heart Journal·Albert WiegmanUNKNOWN European Atherosclerosis Society Consensus Panel
Jul 14, 2017·Journal of Lipid Research·Andrew C MartinGerald F Watts
Nov 14, 2003·Blood Coagulation & Fibrinolysis : an International Journal in Haemostasis and Thrombosis·Takashi SanoJunichiro Yamamoto
May 25, 2002·Drugs & Aging·Michael H DavidsonKate A Ingram
Mar 6, 2004·Journal of Physiology and Biochemistry·L A MorenoM Bueno
Mar 10, 2010·Expert Opinion on Pharmacotherapy·D Meeike KustersBarbara A Hutten
Aug 29, 2000·Pediatric Annals·B W McCrindle
Apr 20, 2005·Obesity Reviews : an Official Journal of the International Association for the Study of Obesity·M H PittlerE Ernst
Oct 21, 2009·Nutrition in Clinical Practice : Official Publication of the American Society for Parenteral and Enteral Nutrition·Matthew V Potenza, Jeffrey I Mechanick
Nov 24, 1999·The American Journal of Cardiology·K C MakiB P Daggy
Mar 4, 2008·Journal of the American Dietetic Association·Jason M Hollander, Jeffrey I Mechanick

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