A Public Health initiative on hepatitis E virus epidemiology, safety and control in Portugal--study protocol

BMC Infectious Diseases
João R MesquitaM S J Nascimento

Abstract

The discovery of autochthonous hepatitis E in industrialized countries has changed the understanding of hepatitis E virus (HEV) infection in these regions, now known to be mainly due to zoonotic transmission of genotype 3. The foodborne route of transmission via consumption of contaminated meat from HEV infected pigs is well documented as well as the direct occupational exposure to animal reservoirs. Accumulating evidence also points to an emerging potential threat to blood safety after the identification of viremic blood donors and the documentation of HEV-contaminated blood or blood products. Moreover, the origin of several iatrogenic cases remains unclear and porcine-derived pharmaceutic products have been suspected as a cause. Severe morbidity following HEV infection in patients receiving immunosuppressive therapy and in those with severe immunodeficiency from other causes has been recently recognized as a serious consequence of this infection in industrialized countries. In Portugal no large-scale HEV seroprevalence study has been undertaken, no professional risk groups have been identified, and the risk of blood donation from HEV silent infected donors is unknown. The present paper describes seroepidemiological and molecu...Continue Reading

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Citations

Dec 30, 2016·The Pediatric Infectious Disease Journal·Ricardo OliveiraMaria São José Nascimento
Dec 14, 2017·European Journal of Public Health·Maria S J NascimentoJoão R Mesquita
Oct 23, 2016·Medical Microbiology and Immunology·J TeixeiraM S J Nascimento
Apr 30, 2017·Euro Surveillance : Bulletin Européen Sur Les Maladies Transmissibles = European Communicable Disease Bulletin·Dragoslav DomanovićPatricia Hewitt

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