May 16, 2014

Amphetamine reduces utility encoding and stabilizes neural dynamics in rat anterior cingulate cortex

BioRxiv : the Preprint Server for Biology
Susana MartínSantiago F. Elena

Abstract

The anterior cingulate cortex (ACC) appears to support decisions by encoding the effort-reward utility of choice options. We show here that d-amphetamine (AMPH) has dose-dependent effects on this encoding and on neural dynamics in rat ACC that are concordant with its behavioral effects. Low-dose AMPH increased task engagement and had mild effects on neural encoding, whereas high doses disrupted utility signaling and decreased task engagement. The disruption involved reduced reward signaling and compressed effort-reward encoding of utility cells, which corresponded with reduced reward consumption behaviors. Furthermore, low-dose AMPH stabilized and accelerated trajectories of neural activity in state-space, whereas high-dose AMPH destabilized trajectories. We propose that low-dose AMPH increases both excitability and stability, which preserves information and accelerates evolution of a neural ‘script’ for task execution. Excessive excitability at high doses overcomes stability enhancement to suppress weakly encoded features (e.g. reward) and cause deviation from the script, which interrupts task performance.

  • References
  • Citations

References

  • We're still populating references for this paper, please check back later.
  • References
  • Citations

Citations

  • This paper may not have been cited yet.

Mentioned in this Paper

Cytidine Deaminase
Exertion
Virus
Genes
Cauliflower Mosaic Virus
Non-Functioning Endocrine Neoplasm
APOBEC3 protein, human
Genome Encoded Entity
Arabidopsis thaliana extract
Osteopetrosis Lethal

Related Feeds

Antivirals

Antivirals are medications that are used specifically for treating viral infections. Discover the latest research on antivirals here.

BioRxiv & MedRxiv Preprints

BioRxiv and MedRxiv are the preprint servers for biology and health sciences respectively, operated by Cold Spring Harbor Laboratory. Here are the latest preprint articles (which are not peer-reviewed) from BioRxiv and MedRxiv.

Antivirals (ASM)

Antivirals are medications that are used specifically for treating viral infections. Discover the latest research on antivirals here.