PMID: 9531567May 16, 1998Paper

A putative catenin-cadherin system mediates morphogenesis of the Caenorhabditis elegans embryo

The Journal of Cell Biology
M CostaJ R Priess

Abstract

During morphogenesis of the Caenorhabditis elegans embryo, hypodermal (or epidermal) cells migrate to enclose the embryo in an epithelium and, subsequently, change shape coordinately to elongate the body (Priess, J.R., and D.I. Hirsh. 1986. Dev. Biol. 117:156- 173; Williams-Masson, E.M., A.N. Malik, and J. Hardin. 1997. Development [Camb.]. 124:2889-2901). We have isolated mutants defective in morphogenesis that identify three genes required for both cell migration during body enclosure and cell shape change during body elongation. Analyses of hmp-1, hmp-2, and hmr-1 mutants suggest that products of these genes anchor contractile actin filament bundles at the adherens junctions between hypodermal cells and, thereby, transmit the force of bundle contraction into cell shape change. The protein products of all three genes localize to hypodermal adherens junctions in embryos. The sequences of the predicted HMP-1, HMP-2, and HMR-1 proteins are related to the cell adhesion proteins alpha-catenin, beta-catenin/Armadillo, and classical cadherin, respectively. This putative catenin-cadherin system is not essential for general cell adhesion in the C. elegans embryo, but rather mediates specific aspects of morphogenetic cell shape change ...Continue Reading

References

Aug 1, 1991·The Journal of Cell Biology·R Francis, R H Waterston
Jan 15, 1971·Science·N K WessellsK Yamada
Nov 1, 1983·Developmental Biology·J E SulstonJ N Thomson
Jan 1, 1984·Developmental Biology·D G Albertson
Sep 12, 1995·Proceedings of the National Academy of Sciences of the United States of America·D L RimmJ S Morrow
Aug 16, 1994·Proceedings of the National Academy of Sciences of the United States of America·L LarueR Kemler
Sep 1, 1994·The Journal of Cell Biology·A R MenkelB M Jockusch
Feb 1, 1994·The Journal of Cell Biology·M C HreskoR H Waterston
Feb 1, 1994·Developmental Biology·B Podbilewicz, J G White
Jan 1, 1993·Genes & Development·P E YoungD P Kiehart
Dec 13, 1996·The Journal of Biological Chemistry·L M PaiM Peifer
Feb 4, 1997·Proceedings of the National Academy of Sciences of the United States of America·M TorresP Gruss
Apr 15, 1997·Developmental Biology·M CostaJ R Priess

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Citations

Feb 8, 2000·The Journal of Comparative Neurology·A Younossi-HartensteinV Hartenstein
Feb 13, 2001·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·G H Thomas
Sep 5, 2002·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·Hendrik C Korswagen
Dec 5, 2000·Trends in Genetics : TIG·I D Chin-Sang, A D Chisholm
Apr 25, 2000·Progress in Neurobiology·C Redies
Oct 17, 2001·Gene·G MichauxM Labouesse
Feb 13, 2001·Current Opinion in Cell Biology·V Vasioukhin, E Fuchs
Sep 17, 2002·Current Opinion in Cell Biology·Doris Wedlich
Oct 6, 1999·Current Opinion in Cell Biology·U Tepass
Feb 27, 1999·Current Opinion in Cell Biology·J D Sutherland, W Witke
Aug 30, 2003·Trends in Cell Biology·Juliet C Coates
Aug 30, 2000·Microbes and Infection·T LauwaetA Leroy
Sep 12, 2008·Nature·Sylvia E J FischerGary Ruvkun
Jul 2, 2003·Nature Cell Biology·Ulrich Tepass
Jun 24, 2003·Nature Cell Biology·Jeffrey S SimskeJeff Hardin
Jun 24, 2010·Nature Reviews. Molecular Cell Biology·Tony J C Harris, Ulrich Tepass
Aug 31, 2012·Nature Reviews. Molecular Cell Biology·Aparna Ratheesh, Alpha S Yap
Sep 2, 2010·Proceedings of the National Academy of Sciences of the United States of America·Aaron P Putzke, Joel H Rothman
Aug 7, 2010·Proceedings of the National Academy of Sciences of the United States of America·Adam V KwiatkowskiJeff Hardin
Jan 19, 2007·Molecular Biology of the Cell·Tamar GattegnoBenjamin Podbilewicz
Jan 13, 2010·Cold Spring Harbor Perspectives in Biology·Matthieu Cavey, Thomas Lecuit
May 23, 2002·Genes & Development·Hendrik C KorswagenHans C Clevers
Jul 27, 2002·Annual Review of Cell and Developmental Biology·Frieder Schock, Norbert Perrimon
Jan 10, 2008·Annual Review of Cell and Developmental Biology·Susan E Mango
Apr 4, 2009·Neural Development·Valentin SchwarzHarald Hutter
Oct 24, 2008·Journal of Cell Science·Andrew ChenLeonid V Chernomordik
Sep 17, 2013·PLoS Genetics·Jeffrey P RasmussenJames R Priess
Apr 21, 2010·PloS One·Gayla HadwigerMichael L Nonet

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