A putative voltage-gated sodium channel alpha subunit (PpSCN1) from the hydrozoan jellyfish, Polyorchis penicillatus: structural comparisons and evolutionary considerations

Biochemical and Biophysical Research Communications
J D SpaffordW J Gallin

Abstract

Extant cnidarians are probably the simplest metazoans with discrete nervous systems and rapid, transient voltage-gated currents carried exclusively by Na+ ions. Thus cnidarians are pivotal organisms for studying the evolution of voltage-gated Na+ channels. We have isolated a full-length Na+ channel alpha subunit cDNA (PpSCN1) from the hydrozoan jellyfish, Polyorchis penicillatus, that has one of the smallest known coding regions of a four domain Na+ channel (1695 amino acids). Homologous residues that have a critical bearing on the selectivity filter, voltage-sensor and binding sites for tetrodotoxin and lidocaine in vertebrates and most invertebrates differ in cnidarians. PpSCN1 is not alternatively-spliced and may be the only pore-forming alpha subunit available to account for at least three electrophysiologically distinct Na+ currents that have been studied in P. penicillatus.

References

Jun 11, 1992·Proceedings of the National Academy of Sciences of the United States of America·A L GeorgeM M Tamkun
Oct 15, 1992·Proceedings of the National Academy of Sciences of the United States of America·D T Campbell
Jul 15, 1992·Biochemical and Biophysical Research Communications·C Sato, G Matsumoto
Feb 1, 1991·Biochemistry and Cell Biology = Biochimie Et Biologie Cellulaire·W Gallin
Oct 5, 1990·Journal of Molecular Biology·S F AltschulD J Lipman
May 23, 1985·Neuroscience Letters·C R French, P W Gage
Mar 22, 1988·Proceedings of the Royal Society of London. Series B, Containing Papers of a Biological Character·F DubasP A Anderson
Feb 6, 1985·Nature·G O Mackie, R W Meech
Apr 1, 1984·Proceedings of the National Academy of Sciences of the United States of America·G M Church, W Gilbert
Jun 1, 1995·Current Opinion in Neurobiology·J P Adelman
May 19, 1995·The Journal of Biological Chemistry·J C McPheeW A Catterall
Nov 1, 1993·Proceedings of the National Academy of Sciences of the United States of America·J J Rosenthal, W F Gilly
Aug 1, 1993·Proceedings of the National Academy of Sciences of the United States of America·P A AndersonR M Greenberg
Jun 1, 1996·The Journal of Membrane Biology·S Cukierman
Jun 1, 1996·Journal of Bioenergetics and Biomembranes·W A Catterall
Oct 1, 1996·Journal of Neurophysiology·N G GrigorievA N Spencer

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Citations

May 18, 2011·Proceedings of the National Academy of Sciences of the United States of America·Benjamin J LiebeskindHarold H Zakon
Jul 12, 2002·The EMBO Journal·Abhijit A PatelJoan A Steitz
Oct 7, 2010·Molecular Biology and Evolution·Jenny WidmarkDan Larhammar
Feb 12, 2014·Pflügers Archiv : European journal of physiology·A SenatoreJ D Spafford
Feb 28, 2013·Channels·Adriano Senatore, J David Spafford
Dec 20, 2003·Nature Reviews. Molecular Cell Biology·Abhijit A Patel, Joan A Steitz
Oct 4, 2017·The Journal of Biological Chemistry·Jean CheminJ David Spafford
Mar 31, 2006·Natural Product Reports·Lyndon E Llewellyn
Feb 20, 2015·The Journal of Experimental Biology·Yehu MoranHarold H Zakon
Apr 13, 1999·Genomics·N W Plummer, M H Meisler
Mar 27, 2001·Insect Biochemistry and Molecular Biology·Z LiuK Dong

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