A quantitative analysis of bone lamellarity and bone collagen linearity induced by distinct dosing and frequencies of teriparatide administration in ovariectomized rats and monkeys.

Microscopy
Takanori SatoTadahiro Iimura

Abstract

The lamellar structure of bone, which endows biomechanical rigidity to support the host organism, is observed in mammals, including humans. It is therefore essential to develop a quantitative analysis to evaluate the lamellarity of bone, which would especially be useful for the pharmacological evaluation of anti-osteoporotic drugs. This study applied a current system for the semi-automatic recognition of fluorescence signals to the analysis of un-decalcified bone sections from rat and monkey specimens treated with teriparatide (TPTD). Our analyses on bone formation pattern and collagen topology indicated that TPTD augmented bone lamellarity and bone collagen linearity, which were possibly associated with the recovery of collagen cross-linking, thus endowing bone rigidity.

References

Dec 1, 1987·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·A M ParfittR R Recker
Jan 1, 1980·Calcified Tissue International·D B Kimmel, W S Jee
Jan 1, 1993·Calcified Tissue International·G Marotti
May 29, 1998·Critical Reviews in Oral Biology and Medicine : an Official Publication of the American Association of Oral Biologists·J P Gorski
Sep 4, 1999·Journal of Structural Biology·S WeinerH D Wagner
Jan 21, 2006·The Journal of Endocrinology·John T Potts
Dec 22, 2006·Drugs·Marit D Moen, Lesley J Scott
Oct 1, 2008·Optics Express·Christophe OdinYann Le Grand
Feb 24, 2009·Calcified Tissue International·Timothy G BromageAlan Boyde
Jan 1, 2008·Journal of the Mechanical Behavior of Biomedical Materials·Markus J Buehler
Oct 21, 2010·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·M SaitoT Kuroda
Sep 29, 2011·Journal of Endocrinological Investigation·B C SilvaJ P Bilezikian
Jan 27, 2012·Journal of the Royal Society, Interface·Elham HamedTadeusz Liszka
May 3, 2012·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Laurie K McCauley, T John Martin
Jul 14, 2012·Journal of Biophotonics·Riccardo CicchiFrancesco Saverio Pavone
Dec 1, 2012·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·David W DempsterA Michael Parfitt
Jan 8, 2013·Journal of Morphology·Gastone MarottiCarla Palumbo
Aug 27, 2013·Journal of the Mechanical Behavior of Biomedical Materials·Elham Hamed, Iwona Jasiuk
Aug 26, 2014·Journal of the Mechanical Behavior of Biomedical Materials·Baptiste DepalleMarkus J Buehler
Mar 18, 2015·Biomedical Optics Express·Hiroshi KiyomatsuTakeshi Imamura
Sep 10, 2015·Journal of Clinical Densitometry : the Official Journal of the International Society for Clinical Densitometry·Sharon H Chou, Tamara Vokes
Nov 4, 2015·PeerJ·Christian KolbMarcelo R Sánchez-Villagra
Feb 9, 2016·Interface Focus·Fereshteh A SabetIwona Jasiuk
Dec 8, 2016·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Felicia CosmanDavid W Dempster
Feb 6, 2017·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Paula Suarez-BreguaJosep Rotllant
Nov 1, 1987·Evolution; International Journal of Organic Evolution·John A Ruben, Albert A Bennett
Jul 18, 2017·European Journal of Radiology·Wojciech M Glinkowski, Jerzy Narloch
Sep 12, 2017·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Paula Suarez-BreguaJosep Rotllant
Oct 19, 2017·PloS One·Paula Suarez-BreguaJosep Rotllant
Aug 9, 2019·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·T SugimotoT Nakamura
Nov 2, 2019·Bone·Hajar RaziPeter Fratzl

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