A quantitative analysis of carbon-ion beam-induced reactive oxygen species and redox reactions

Journal of Clinical Biochemistry and Nutrition
Ken-Ichiro MatsumotoIkuo Nakanishi

Abstract

The amounts of reactive oxygen species generated in aqueous samples by irradiation with X-ray or clinical carbon-ion beams were quantified. Hydroxyl radical (•OH), hydrogen peroxide (H2O2), and the total amount of oxidation reactions, which occurred mainly because of •OH and/or hydroperoxy radicals (HO2•), were measured by electron paramagnetic resonance-based methods. •OH generation was expected to be localized on the track/range of the carbon-ion beam/X-ray, and mM and M levels of •OH generation were observed. Total •OH generation levels were identical at the same dose irrespective of whether X-ray or carbon-ion beam irradiation was used, and were around 0.28-0.35 µmol/L/Gy. However, sparse •OH generation levels decreased with increasing linear energy transfer, and were 0.17, 0.15, and 0.09 µmol/L/Gy for X-ray, 20 keV/µm carbon-ion beam, and >100 keV/µm carbon-ion beam sources, respectively. H2O2 generation was estimated as 0.26, 0.20, and 0.17 µmol/L/Gy, for X-ray, 20 keV/µm carbon-ion beam, and >100 keV/µm carbon-ion beam sources, respectively, whereas the ratios of H2O2 generation per oxygen consumption were 0.63, 0.51, and 3.40, respectively. The amounts of total oxidation reactions were 2.74, 1.17, and 0.66 µmol/L/Gy, re...Continue Reading

References

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Oct 5, 2010·Magnetic Resonance in Medical Sciences : MRMS : an Official Journal of Japan Society of Magnetic Resonance in Medicine·Ken-ichiro MatsumotoKazunori Anzai
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Jan 17, 2012·Journal of Clinical Biochemistry and Nutrition·Ken-Ichiro MatsumotoKazunori Anzai
Mar 26, 2013·Journal of Clinical Biochemistry and Nutrition·Megumi UenoKen-Ichiro Matsumoto
Mar 12, 2015·Chemical & Pharmaceutical Bulletin·Ken-ichiro MatsumotoKazunori Anzai
Oct 4, 2018·Journal of Clinical Biochemistry and Nutrition·Yukihiro OgawaKen-Ichiro Matsumoto

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Citations

May 27, 2020·Free Radical Research·Megumi UenoKen-Ichiro Matsumoto
Aug 26, 2019·Free Radical Biology & Medicine·Mizuki NakamuraKen-Ichiro Matsumoto
Mar 18, 2021·Free Radical Research·Ken-Ichiro MatsumotoIkuo Nakanishi
Jun 22, 2021·Antioxidants & Redox Signaling·Ken-Ichiro MatsumotoIchio Aoki

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Methods Mentioned

BETA
electron paramagnetic resonance
X-ray
irradiate

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