A quantitative analysis of cell volume and resting potential determination and regulation in excitable cells

The Journal of Physiology
James A Fraser, Christopher L-H Huang

Abstract

This paper quantifies recent experimental results through a general physical description of the mechanisms that might control two fundamental cellular parameters, resting potential (Em) and cell volume (Vc), thereby clarifying the complex relationships between them. Em was determined directly from a charge difference (CD) equation involving total intracellular ionic charge and membrane capacitance (Cm). This avoided the equilibrium condition dEm/dt = 0 required in determinations of Em by previous work based on the Goldman-Hodgkin-Katz equation and its derivatives and thus permitted precise calculation of Em even under non-equilibrium conditions. It could accurately model the influence upon Em of changes in Cm or Vc and of membrane transport processes such as the Na+-K+-ATPase and ion cotransport. Given a stable and adequate membrane Na+-K+-ATPase density (N), Vc and Em both converged to unique steady-state values even from sharply divergent initial intracellular ionic concentrations. For any constant set of transmembrane ion permeabilities, this set point of Vc was then determined by the intracellular membrane-impermeant solute content (X-i) and its mean charge valency (zX), while in contrast, the set point of Em was determined...Continue Reading

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