Abstract
Patients with presumptive Alzheimer's disease (AD) and healthy community volunteers received computed tomographic (CT) brain scans and cognitive tests. The CT scans were quantitatively analyzed with a semiautomated thresholding technique to derive volumetric measures of cerebrospinal fluid (CSF)-to-tissue ratios in six regions of interest (ROIs): lateral ventricles; vertex sulci, frontal sulci, Sylvian fissures, parieto-occipital sulci, and third ventricle. Regression analysis was performed on CT data from 85 older volunteers (ages 51-82) to generate age norms for each ROI. Within this group, tissue loss, as measured by the % CSF in each ROI, was highly correlated with age, although each ROI showed different rates of change over age. For all ROIs, the AD group had significantly more tissue loss than expected in normal aging. In addition, AD patients with a presenescent onset (before age 65) tended to have greater vertex sulcal and frontal sulcal tissue reduction than AD patients with a senescent onset (age 65 or after). When regional tissue reduction, corrected for age, was correlated with cognitive test scores, two sets of double dissociations emerged within the AD group: large CT z scores (i.e., decreased tissue and increased...Continue Reading
References
Dec 1, 1979·Cortex; a Journal Devoted to the Study of the Nervous System and Behavior·F Mazzocchi, L A Vignolo
Dec 31, 1977·Neuroradiology·C Gyldensted
Nov 1, 1976·Neurology·S A BarronW R Kinkel
Sep 1, 1975·Archives of Neurology·V C HachinskiL Symon
Apr 1, 1990·Psychiatry Research·R B ZipurskyA Pfefferbaum
Dec 1, 1989·Journal of Clinical and Experimental Neuropsychology·E V SullivanJ H Growdon
Jul 1, 1989·Journal of Computer Assisted Tomography·K O Lim, A Pfefferbaum
Nov 1, 1985·Archives of Neurology·Z S Khachaturian
Aug 15, 1988·Annals of Internal Medicine·R P FriedlandJ Kaye
Oct 1, 1988·Journal of Clinical and Experimental Neuropsychology·C L GradyS I Rapoport
Jan 1, 1988·Neurology·L A HansenR D Terry
Jul 1, 1988·Archives of General Psychiatry·A PfefferbaumT L Jernigan
Oct 1, 1986·Journal of Clinical and Experimental Neuropsychology·A MartinT N Chase
Jul 1, 1987·Neurology·J S LuxenbergS I Rapoport
Jan 1, 1986·Neuropsychologia·E K WarringtonC Maciejewski
Jul 1, 1986·Brain and Language·F J HuffJ H Growdon
Jul 1, 1986·Journal of Computer Assisted Tomography·A PfefferbaumT L Jernigan
Sep 1, 1986·Neurology·B PillonY Agid
Feb 1, 1985·Annals of Neurology·M SchwartzS I Rapoport
Apr 1, 1985·Neurology·R MayeuxS Spanton
Nov 1, 1985·Psychological Medicine·R R JacobsonW A Lishman
Jun 25, 1983·Lancet·W Bondareff
Mar 31, 1984·British Medical Journal·M N RossorM Roth
Mar 1, 1984·The Journal of Clinical Endocrinology and Metabolism·P MadvigR Marcus
Jul 1, 1984·Neurology·G McKhannE M Stadlan
Jan 1, 1984·Annals of Neurology·T N ChaseG Di Chiro
Aug 1, 1982·Psychiatry Research·T L JerniganJ A Moses
Mar 1, 1980·The British Journal of Psychiatry : the Journal of Mental Science·R J JacobyJ M Dawson
Mar 1, 1981·Journal of Gerontology·C V Ford, J Winter
Jan 1, 1957·Annual Review of Psychology·E STELLAR
Feb 1, 1957·Journal of Consulting Psychology·T D OLIN, M REZNIKOFF
Jan 1, 1955·Annual Review of Psychology·H L TEUBER
Mar 8, 2005·European Journal of Nuclear Medicine and Molecular Imaging·Jyrki T Kuikka
Citations
Oct 7, 2008·Brain Imaging and Behavior·Lisa M NewmanSterling C Johnson
Jun 24, 2011·Neuroinformatics·Peter KochunovJack Lancaster
Feb 1, 1996·Journal of the Neurological Sciences·A B Newberg, A Alavi
Nov 1, 1993·Neurobiology of Aging·M Albert
Dec 1, 1993·Psychiatry Research·A PfefferbaumK O Lim
Jun 1, 1993·Psychiatry Research·D H MathalonA Pfefferbaum
Jun 18, 2005·Biological Psychology·Anke KarlAndreas Maercker
Sep 7, 2001·Advances in Space Research : the Official Journal of the Committee on Space Research (COSPAR)·A B Newberg, A Alavi
Oct 1, 1998·Psychiatry Research·F LazeyrasK R Krishnan
Jul 1, 1992·Journal of Clinical and Experimental Neuropsychology·D FriedmanK Marder
Dec 1, 1992·Alcoholism, Clinical and Experimental Research·A PfefferbaumE V Sullivan
Jan 1, 1996·Acta Neurologica Scandinavica. Supplementum·L O Wahlund
Jul 1, 1992·Annals of the New York Academy of Sciences·D Friedman
Feb 10, 2011·The Journal of Neuropsychiatry and Clinical Neurosciences·Allison R KaupLisa T Eyler
Sep 15, 2005·Human Brain Mapping·Peter KochunovPeter T Fox
Jan 1, 1993·Pediatric Radiology·G FarielloP Tomà
Nov 1, 1992·Arthritis and Rheumatism·C T RitchlinS B Abramson
Aug 19, 2015·Neuropsychology Review·Erin D Bigler