Jan 22, 2016

A Quantitative Analysis of Localized Robustness of MYCN in Neuroblastoma

BioRxiv : the Preprint Server for Biology
Romeil SandhuAllen Tannenbaum

Abstract

The amplification of the gene MYCN (V-myc myelocytomatosis viral-valeted oncogene, neuroblastoma derived) has been a well-documented indicator for poor prognosis in neuroblastoma, a childhood cancer. Unfortunately, there has been limited success in understanding MYCN functionality in the landscape of neuroblastoma and more importantly, given that MYCN has been deemed "undruggable," the need to potentially illuminate key opportunities that indirectly target MYCN is of great interest. To this end, this work employs an emerging quantitative technique from network science, namely network curvature, to quantify the biological robustness of MYCN and its surrounding neighborhood. In particular, when amplified in Stage IV cancer, MYCN exhibits higher curvature (more robust) than those samples with under expressed MYCN levels. When examining the surrounding neighborhood, the above argument still holds for network curvature, but is lost when only analyzing differential expression - a common technique amongst oncologists and computational/molecular biologists. This finding points to the problem (and possible solution) of drug targeting in the context of complexity and indirect cell signaling affects that have often been obfuscated through...Continue Reading

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Mentioned in this Paper

MYCN gene
Malignant Neoplasm of Ovary Stage IV
Central Neuroblastoma
Oncologist
MYCN protein, human
Gene Amplification Technique
Neuroblastoma
MYCN wt Allele
Intercellular Communication Process
Pharmacologic Substance

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