A Quantitative Approach to SIV Functional Latency in Brain Macrophages.

Journal of Neuroimmune Pharmacology : the Official Journal of the Society on NeuroImmune Pharmacology
Celina M AbreuJanice E Clements

Abstract

Lentiviruses are retroviruses that primarily infect myeloid cells, leading to acute inflammatory infections in many tissues particularly, lung, joints and the central nervous system (CNS). Acute infection by lentiviruses is followed by persistent/latent infections that are not cleared by the host immune system. HIV and SIV are lentiviruses that also infect CD4+ lymphocytes as well as myeloid cells in blood and multiple tissues. HIV infection of myeloid cells in brain, lung and heart cause tissue specific diseases as well as infect cells in gut, lymph nodes and spleen. AIDS dementia and other tissue specific disease are observed when infected individuals are immunosuppressed and the number of circulating CD4+ T cells declines to low levels. Antiretroviral therapy (ART) controls viral spread and dramatically changes the course of immunodeficiency and AIDS dementia. However, ART does not eliminate virus-infected cells. Brain macrophages contain HIV DNA and may represent a latent reservoir that persists. HIV latency in CD4+ lymphocytes is the main focus of current research and concern in efforts to eradicate HIV. However, a number of studies have demonstrated that myeloid cells in blood and tissues of ART suppressed individuals har...Continue Reading

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Citations

Mar 27, 2020·Current Opinion in Neurology·Justin C McArthur, Tory P Johnson
Feb 10, 2019·Journal of Neuroimmune Pharmacology : the Official Journal of the Society on NeuroImmune Pharmacology·Tricia H Burdo
Jul 13, 2019·Frontiers in Immunology·Michelle E WongAnna C Hearps
Nov 12, 2019·Frontiers in Cellular and Infection Microbiology·Clementine WalletChristian Schwartz
Oct 28, 2019·Frontiers in Immunology·Sarah E BeckJoel N Blankson
Aug 29, 2021·Pathogens·Sonia MorettiAlessandra Borsetti
Aug 28, 2021·Biomedicines·Ana Borrajo LópezRoberto Carlos Agís-Balboa

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Methods Mentioned

BETA
histone acetylation
PCR

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