A quantitative assessment of dynamical differences of RSV infections in vitro and in vivo

Virology
Gilberto Gonzàlez-Parra, Hana M Dobrovolny

Abstract

Experimental results in vitro and in animal models are used to guide researchers in testing vaccines or treatment in humans. However, viral kinetics are different in vitro, in animals, and in humans, so it is sometimes difficult to translate results from one system to another. In this study, we use a mathematical model to fit experimental data from multiple cycle respiratory syncytial virus (RSV) infections in vitro, in african green monkey (AGM), and in humans in order to quantitatively compare viral kinetics in the different systems. We find that there are differences in viral clearance rate, productively infectious cell lifespan, and eclipse phase duration between in vitro and in vivo systems and among different in vivo systems. We show that these differences in viral kinetics lead to different estimates of drug effectiveness of fusion inhibitors in vitro and in AGM than in humans.

Citations

Apr 24, 2019·Journal of Mathematical Biology·Gilberto González-Parra, Hana M Dobrovolny
Dec 30, 2020·Microorganisms·Sonia BianchiniSusanna Esposito
Apr 13, 2021·Virus Research·Thalia Rodriguez, Hana M Dobrovolny
May 9, 2021·Journal of Theoretical Biology·Benjamin Jessie, Hana M Dobrovolny
Jul 31, 2021·Virus Research·Shaheer Khan, Hana M Dobrovolny

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