A quantitative assessment of T-wave morphology in LQT1, LQT2, and healthy individuals based on Holter recording technology

Heart Rhythm : the Official Journal of the Heart Rhythm Society
Martino VaglioWojciech Zareba

Abstract

The clinical course and the precipitating risk factors in the congenital long QT syndrome (LQTS) are genotype specific. The goal of this study was to develop a computer algorithm allowing for electrocardiogram (ECG)-based identification and differentiation of LQT1 and LQT2 carriers. Twelve-lead ECG Holter monitor recordings were acquired in 49 LQT1 carriers, 25 LQT2 carriers, and 38 healthy subjects as controls. The cardiac beats were clustered based on heart-rate bin method. Scalar and vectorial repolarization parameters were compared for similar heart rates among study groups. The Q to Tpeak (QTpeak), the Tpeak to Tend interval, T-wave magnitude and T-loop morphology were automatically quantified using custom-made algorithms. QTpeak from lead II and the right slope of the T-wave were the most discriminant parameters for differentiating the 3 groups using prespecified heart rate bin (75.0 to 77.5 beats/min). The predictive model utilizing these scalar parameters was validated using the entire spectrum of heart rates. Both scalar and vectorcardiographic models provided very effective identification of tested subjects in heart rates between 60 and 100 beats/min, whereas they had limited performance during tachycardia and slightl...Continue Reading

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Citations

Mar 28, 2009·Philosophical Transactions. Series A, Mathematical, Physical, and Engineering Sciences·Jean-Philippe Couderc
Oct 7, 2008·American Journal of Physiology. Heart and Circulatory Physiology·Katja E OdeningGideon Koren
May 9, 2012·Journal of Electrocardiology·Anna-Mari HekkalaToivonen Lauri
Mar 17, 2010·Heart Rhythm : the Official Journal of the Heart Rhythm Society·Ishvinder S ChatthaAndrew D Krahn
Oct 29, 2008·Journal of Electrocardiology·Fabio BadiliniPierre Maison-Blanche
Sep 20, 2008·Journal of Electrocardiology·Jean-Philippe CoudercWojciech Zareba
Jan 30, 2009·Annals of Noninvasive Electrocardiology : the Official Journal of the International Society for Holter and Noninvasive Electrocardiology, Inc·Fabrice ExtramianaPierre Maison-Blanche
Feb 12, 2010·Annals of Noninvasive Electrocardiology : the Official Journal of the International Society for Holter and Noninvasive Electrocardiology, Inc·Fabrice ExtramianaPierre Maison-Blanche
Oct 22, 2008·Heart Rhythm : the Official Journal of the Heart Rhythm Society·Michael R Franz
Aug 24, 2010·Journal of Electrocardiology·Jean-Philippe Couderc, Coeli M Lopes
Jul 14, 2016·Circulation. Arrhythmia and Electrophysiology·Alan SugrueMichael J Ackerman
Apr 23, 2011·Circulation. Arrhythmia and Electrophysiology·Hitoshi HorigomeMasao Yoshinaga
Aug 12, 2016·Physiological Measurement·S A ImmanuelJ I Vandenberg
Aug 3, 2017·The Medical Journal of Australia·Kathryn Waddell-SmithJonathan R Skinner
Dec 17, 2010·Cardiovascular Research·Maura GreiserUlrich Schotten
Dec 9, 2017·Pacing and Clinical Electrophysiology : PACE·Christopher W FollansbeeGaurav Arora
May 16, 2018·JACC. Clinical Electrophysiology·Jean-Philippe Couderc, Wojciech Zareba
Jul 10, 2021·Circulation. Arrhythmia and Electrophysiology·Elizabeth S KaufmanWojciech Zareba

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