PMID: 5178May 14, 1976Paper

A quantitative comparison of the formation of synapses in the rat superior cervical sympathetic ganglion by its own and by foreign nerve fibres

Brain Research
A OstbergR E Zigmond

Abstract

The rat superior cervical sympathetic ganglion (SCG) has about 36,000 neurones in a volume of about 1 cu.mm. There are about 8.8 X 10(6) synapses, and 6000-9000 preganglionic axons. Section of the preganglionic chain causes a loss of 93% of the synapses. In the denervated SCG there are 0.6 X 10(6) remaining ('intrinsic') synapses, and a proportion of the synaptic sites are identifiable as vacated synaptic thickenings (3 X 10(6) per SCG, as compared with 0.5 X 10(6) in the normal intact SCG). After deducting the intrinsic synapses, this indicates that each preganglionic axon forms about 1100 (900-1400) synapses. After freezing the preganglionic chain, subsequent axonal regeneration restores synapse numbers to 85% of normal (7.5 X 10(6) synapses per SCG). After anastomotic repair by suture of the cut ends of the preganglionic chain (a necessary control for the foreign nerve anastomoses), the SCG contains only 60% of the normal complement of synapses (5.2 X 10(6) synapses per SCG). The results of this anastomosis are very variable. However, in individual ganglia the numbers of synapses are directly correlated with the numbers of axons which reach the SCG. After deducting the intrinsic synapses it can be calculated that each axon f...Continue Reading

References

Dec 1, 1971·Proceedings of the National Academy of Sciences of the United States of America·D C KleinR Y Moore
Apr 18, 1972·Proceedings of the Royal Society of London. Series B, Containing Papers of a Biological Character·M R Matthews, G Raisman
Apr 12, 1972·Nature: New Biology·P R LewisV Navaratnam
Jan 1, 1972·Brain : a Journal of Neurology·P J Dyck, A P Hopkins
Nov 1, 1972·Analytical Biochemistry·T Deguchi, J Axelrod
May 1, 1970·Acta Physiologica Scandinavica·J Hanson, L Widén
Jul 1, 1968·The Journal of Cell Biology·S L PalayP M Orkand
Jun 28, 1956·The Journal of Physiology·C O HEBB, G M WAITES
Aug 22, 1904·The Journal of Physiology·J N Langley, H K Anderson
Aug 24, 1934·The Journal of Physiology·H H Dale, W Feldberg

❮ Previous
Next ❯

Citations

Feb 1, 1978·Annals of Neurology·G Raisman
Jul 1, 1995·Brain Research. Brain Research Reviews·F B WangT L Powley
Mar 1, 1984·Journal of the Autonomic Nervous System·I Prigioni, C Casella
May 17, 1995·Journal of the Autonomic Nervous System·D Eugène, J Taxi
Sep 1, 1979·Proceedings of the National Academy of Sciences of the United States of America·W ProctorS Roper
Apr 1, 1982·Proceedings of the National Academy of Sciences of the United States of America·G FriedP Greengard
Dec 1, 1987·Proceedings of the National Academy of Sciences of the United States of America·K Wu, I B Black
Aug 1, 1988·Proceedings of the National Academy of Sciences of the United States of America·K Wu, I B Black
Jan 1, 1979·Neuropathology and Applied Neurobiology·P Bradley, M Berry
Mar 15, 2013·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Jaisri R Lingappa, Richard E Zigmond
Jan 1, 1989·Proceedings of the National Academy of Sciences of the United States of America·F F EbnerS M Lee
Sep 15, 2009·Autonomic Neuroscience : Basic & Clinical·Jason A Luther, Susan J Birren
Jun 1, 1979·Experimental Neurology·R P VeraaR A Ross

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.