PMID: 3766987Jan 1, 1986Paper

A quantitative electron microscopic study of the effect of glucocorticoids in vivo on the early postnatal differentiation of paraneuronal cells in the carotid body and the adrenal medulla of the rat

Anatomy and Embryology
G K von Dalnok, H D Menssen

Abstract

The postnatal differentiation of carotid body chief cells and endocrine adrenal medullary cells was comparatively examined during ontogenesis and in rats which were treated with dexamethasone for 7 days after birth. Ultrastructure and innervation of carotid body chief cells are mature in neonates according to the functional requirements of chemoreception. By the end of the first postnatal week, only an increase in number of dense core vesicles can be noticed, the concentration of which then will reach the adult level. Under the effect of dexamethasone most of the heterochromatin is transformed into finely dispersed euchromatin within the nuclei of carotid body chief cells. In the cytoplasm, the Golgi apparatus becomes larger and the granular endoplasmic reticulum hypertrophic. The number of catecholamines storing dense core vesicles increases considerably. The innervation density remains constant. In contrast to the carotid body chief cells, the adrenal medullary cells have not reached their definitive maturity at the time of birth. Besides phenotypes of adrenaline-cells, noradrenaline-cells and small granules containing cells, pheochromoblasts and intermediary cells can be seen as well. Their cytoplasm is sparse, the concentra...Continue Reading

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Citations

May 26, 2005·Respiratory Physiology & Neurobiology·Zun-Yi Wang, Gerald E Bisgard
Sep 18, 2012·Respiratory Physiology & Neurobiology·John L Carroll, Insook Kim
Jun 26, 2012·Respiratory Physiology & Neurobiology·Raffaele De CaroAndrea Porzionato
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May 15, 1995·The Journal of Comparative Neurology·K Mirnics, H R Koerber
Jan 1, 1996·Microsurgery·T UstünerW C Lineaweaver
May 28, 2004·The Journal of Comparative Neurology·David H RapaportMatthew M LaVail
Feb 11, 2003·The Journal of Comparative Neurology·Jason R CoonanMary P Galea
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Sep 1, 1992·The Anatomical Record·C S JohanssonB Povlsen
Jan 26, 2018·Proceedings. Biological Sciences·Sandra R SchachatC Kevin Boyce

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