A quantitative-genetic analysis of hippocampal variation in the mouse

Journal of Neurogenetics
W E CrusioH Schwegler

Abstract

This report analyses the genetic underpinnings of the proportions of the hippocampal terminal fields in the mouse at the midseptotemporal level. We used 5 inbred strains and all possible F1 crosses between them (diallel cross). Broad heritabilities ranged from 11 to 53%. Additive genetic variation was present for all phenotypes analyzed. Directional dominance was found for the relative size of the suprapyramidal mossy fiber terminal field only. For the stratum lacunosum-moleculare, ambidirectional dominance emerged. These findings suggest that, in evolutionary history, directional selection has operated for a proportionally large suprapyramidal terminal field. For all other hippocampal variables (viz. the relative sizes for the strata oriens, pyramidale, radiatum, lacunosum-moleculare, CA4, intra- and infrapyramidal mossy fiber terminal field and the absolute size of the regio inferior) past stabilizing selection was inferred.

Citations

May 20, 1998·Developmental Psychobiology·W E Crusio, A Schmitt
Jun 1, 1996·Physiology & Behavior·W E Crusio, A Schmitt
Jun 25, 1996·Mechanisms of Ageing and Development·M BarkatsC Cohen-Salmon
Nov 1, 1987·Behavioural Brain Research·W E Crusio, H Schwegler
Feb 1, 1991·Behavioural Processes·D WahlstenB Bulman-Fleming
Oct 30, 2001·Behavioural Brain Research·W E Crusio
Feb 6, 2002·Brain Research Bulletin·Yann S Mineur, Wim E Crusio
Aug 15, 1993·Proceedings of the National Academy of Sciences of the United States of America·D F SherryG O Ivy
May 27, 2005·Behavioral and Brain Functions : BBF·Wim E Crusio, Herbert Schwegler
Oct 10, 2015·Genes, Brain, and Behavior·A DelpratoW E Crusio
Sep 23, 2006·Neurobiology of Learning and Memory·S MiddeiM Ammassari-Teule
May 1, 2011·Wiley Interdisciplinary Reviews. Cognitive Science·Susanna Pietropaolo, Wim E Crusio
Oct 2, 1998·The American Journal of Physiology·P FrankenM Tafti
May 15, 1993·The Journal of Comparative Neurology·P V Hoogland, E Vermeulen-VanderZee
Jul 17, 2021·PLoS Genetics·Patrick B Chen, Jonathan Flint

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