A quantitative immunochemical faecal occult blood test is more efficient for detecting significant colorectal neoplasia than a sensitive guaiac test

Alimentary Pharmacology & Therapeutics
Zohar LeviYaron Niv

Abstract

The sensitive guaiac faecal occult blood test, Haemoccult SENSA (HOS; Beckman Coulter, Fullerton, CA, USA), is our standard screening test for significant colorectal neoplasia. We evaluated an automatically-developed, quantified human haemoglobin immunochemical faecal test, OC-MICRO (Eiken Chemical Co., Tokyo, Japan), to improve test specificity and so reduce the colonoscopy burden. To compare guaiac faecal occult blood test and immunochemical faecal test diagnostic efficacy and costs for identifying significant neoplasia. Colonoscopies were performed on patients who prepared three daily guaiac faecal occult blood tests with or without immunochemical faecal tests. Total colonoscopy was performed on 151 subjects who prepared both guaiac and immunochemical faecal tests (group 1) and the positive predictive values (PPV) were also compared to those of 162 subjects undergoing colonoscopy for positive guaiac faecal occult blood tests (group 2). In group 1, comparative sensitivity, specificity, and PPVs for significant neoplasia with guaiac faecal occult blood test were 75%, 34%, and 12% (PPV, 18% for group 2) and with immunochemical faecal test were 75%, 94% and 60% (P < 0.01 for specificity). The number of colonoscopy examinations n...Continue Reading

References

Aug 1, 1990·Journal of Clinical Gastroenterology·Y Niv
Sep 1, 1994·European Journal of Cancer Prevention : the Official Journal of the European Cancer Prevention Organisation (ECP)·G CastiglioneL Bertario
Jan 18, 1996·The New England Journal of Medicine·J E AllisonA L Adrain
May 12, 1997·Archives of Internal Medicine·B LevinC Johnson
Aug 6, 1998·Alimentary Pharmacology & Therapeutics·J E Allison
Mar 10, 2001·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·H NakamaX Zhang
Oct 19, 2002·The American Journal of Gastroenterology·Graeme P YoungUNKNOWN WHO (World Health Organization) and OMED (World Organization for Digestive Endoscopy)
Jan 25, 2003·The American Journal of Medicine·Roanne R E SelingerJason A Dominitz
Mar 1, 2005·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Ulrike Haug, Hermann Brenner
Jun 3, 2005·The American Journal of Gastroenterology·Daniel L OuyangRobert E Schoen
Sep 7, 2006·The Australian & New Zealand Journal of Obstetrics & Gynaecology·Genia RozenWarren Rozen

❮ Previous
Next ❯

Citations

May 26, 2010·Journal of General Internal Medicine·Alan S Rosman, Mark A Korsten
Apr 27, 2013·Annals of Oncology : Official Journal of the European Society for Medical Oncology·K GarborgM Bretthauer
Jun 29, 2011·Epidemiologic Reviews·Theodore R LevinCindy Caldwell
May 17, 2013·Japanese Journal of Clinical Oncology·Nobuyoshi YamazakiYasuhiro Matsumura
Sep 27, 2007·Journal of the National Cancer Institute·James E AllisonJoseph V Selby
Jul 26, 2012·BMC Gastroenterology·Jochim S Terhaar sive DrosteChris J J Mulder
Dec 25, 2008·Journal of Medical Screening·Grazia GrazziniUNKNOWN Working Group of Regional Reference Centre for Oncological Screening of Tuscany
Mar 6, 2010·World Journal of Gastroenterology : WJG·Motoaki KuriyamaKazuhide Yamamoto
Jan 13, 2011·International Journal of Colorectal Disease·Murugan KalimuthoSergio Bernardini
May 28, 2013·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Hermann Brenner, Sha Tao
Sep 14, 2010·Best Practice & Research. Clinical Gastroenterology·Leonie van DamMonique E van Leerdam
Mar 4, 2008·Gastroenterology Clinics of North America·Jack S Mandel
May 2, 2009·International Journal of Cancer. Journal International Du Cancer·Leo G M van RossumEvelien Dekker
Sep 9, 2010·International Journal of Cancer. Journal International Du Cancer·Michael J DuffyStephen P Halloran
Nov 12, 2014·Frontiers in Public Health·Fabrizio StracciGrazia Grazzini
Feb 29, 2016·Journal of Gastrointestinal Cancer·Andrea IannoneAlfredo Di Leo
Oct 15, 2009·World Journal of Gastrointestinal Endoscopy·Andreas Sieg, Kilian Friedrich
Sep 18, 2007·European Journal of Gastroenterology & Hepatology·Sanna A MulderRob J Th Ouwendijk
Mar 25, 2009·European Journal of Gastroenterology & Hepatology·Antonio Z Gimeno-GarcíaAlejandro Jiménez-Sosa
Oct 22, 2010·European Journal of Gastroenterology & Hepatology·Zohar LeviYaron Niv
Jan 15, 2020·World Journal of Gastroenterology : WJG·Noel Pin-Vieito On Behalf Of The Colonpredict Study Investigators

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.