A quantitative measure of myelination development in infants, using MR images

Neuroradiology
Dennis P CarmodyMichael Lewis

Abstract

The objective of this study was to measure myelination of frontal lobe changes in infants and young children. Twenty-four cases of infants and children (age range 12-121 months) were evaluated by a quantitative assessment of T2-weighted MR image features. Reliable quantitative changes between white and gray matter correlated with developmental age in a group of children with no neurological findings. Myelination appears to be an increasing exponential function with the greatest rate of change occurring over the first 3 years of life. The quantitative changes observed were in accordance with previous qualitative judgments of myelination development. Children with periventricular leukomalacia (PVL) showed delays in achieving levels of myelination when compared to normal children and adjusted for chronological age. The quantitative measure of myelination development may prove to be useful in assessing the stages of development and helpful in the quantitative descriptions of white matter disorders such as PVL.

References

Jan 1, 1990·Brain & Development·M Dambska, M Laure-Kamionowska
Apr 1, 1988·AJR. American Journal of Roentgenology·R B DietrichH Kangarloo
Nov 1, 1988·Journal of Computer Assisted Tomography·E MartinP Kaelin
May 1, 1988·Journal of Neuropathology and Experimental Neurology·H C KinneyF H Gilles
Sep 1, 1993·Early Human Development·Y KonishiY Ishii
Dec 5, 2000·Brain & Development·N Herschkowitz

❮ Previous
Next ❯

Citations

Mar 24, 2006·NeuroRx : the Journal of the American Society for Experimental NeuroTherapeutics·Mathew B PottsLinda J Noble-Haeusslein
Jun 22, 2010·Developmental Psychobiology·Dennis P Carmody, Michael Lewis
Sep 9, 2006·Brain Research·Dennis P Carmody, Michael Lewis
Apr 8, 2020·Journal of Neuroimaging : Official Journal of the American Society of Neuroimaging·Gerhard S DrenthenJacobus F A Jansen

❮ Previous
Next ❯

Related Concepts

Related Feeds

Brain developing: Influences & Outcomes

This feed focuses on influences that affect the developing brain including genetics, fetal development, prenatal care, and gene-environment interactions. Here is the latest research in this field.