A quantitative method for defining high-arched palate using the Tcof1(+/-) mutant mouse as a model

Developmental Biology
Zachary R ConleyPaul A Trainor

Abstract

The palate functions as the roof of the mouth in mammals, separating the oral and nasal cavities. Its complex embryonic development and assembly poses unique susceptibilities to intrinsic and extrinsic disruptions. Such disruptions may cause failure of the developing palatal shelves to fuse along the midline resulting in a cleft. In other cases the palate may fuse at an arch, resulting in a vaulted oral cavity, termed high-arched palate. There are many models available for studying the pathogenesis of cleft palate but a relative paucity for high-arched palate. One condition exhibiting either cleft palate or high-arched palate is Treacher Collins syndrome, a congenital disorder characterized by numerous craniofacial anomalies. We quantitatively analyzed palatal perturbations in the Tcof1(+/-) mouse model of Treacher Collins syndrome, which phenocopies the condition in humans. We discovered that 46% of Tcof1(+/-) mutant embryos and new born pups exhibit either soft clefts or full clefts. In addition, 17% of Tcof1(+/-) mutants were found to exhibit high-arched palate, defined as two sigma above the corresponding wild-type population mean for height and angular based arch measurements. Furthermore, palatal shelf length and shelf wi...Continue Reading

References

Mar 26, 2004·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Jill Dixon, Michael James Dixon
Nov 30, 2005·Journal of Anatomy·Drew M Noden, Paul A Trainor
Aug 30, 2006·Proceedings of the National Academy of Sciences of the United States of America·Jill DixonPaul A Trainor
May 15, 2007·American Journal of Medical Genetics. Part a·Katherine NeiswangerMary L Marazita
Jun 7, 2008·American Journal of Medical Genetics. Part a·Seth M WeinbergMary L Marazita
Nov 4, 2008·Genetics in Medicine : Official Journal of the American College of Medical Genetics·Alexandre R VieiraMary L Marazita
Nov 19, 2009·American Journal of Medical Genetics. Part a·Katherine NeiswangerMary L Marazita
Feb 19, 2011·Nature Reviews. Genetics·Michael J DixonJeffrey C Murray
May 7, 2011·The Cleft Palate-craniofacial Journal : Official Publication of the American Cleft Palate-Craniofacial Association·Fedik RahimovJeffrey C Murray
May 28, 2011·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Kai Yu, David M Ornitz
Aug 30, 2012·Genesis : the Journal of Genetics and Development·Lisa L SandellPaul A Trainor
Jun 29, 2013·Developmental Cell·Jacqueline M TablerKaren J Liu
Sep 3, 2013·Journal of Clinical and Diagnostic Research : JCDR·D Sridhara NarayananRamya Kumar
Jul 10, 2014·North American Journal of Medical Sciences·Amandeep ChopraShelja Vashisth

❮ Previous
Next ❯

Citations

Oct 16, 2018·Wiley Interdisciplinary Reviews. Developmental Biology·Hiroshi Kurosaka
Feb 12, 2017·Wiley Interdisciplinary Reviews. Developmental Biology·Karla TerrazasMichael J Dixon
Oct 10, 2020·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Minghui YueRulang Jiang
Apr 16, 2021·Frontiers in Physiology·Hiroyuki YamaguchiYoshihiro Komatsu

❮ Previous
Next ❯

Related Concepts

Related Feeds

Birth Defects

Birth defects encompass structural and functional alterations that occur during embryonic or fetal development and are present since birth. The cause may be genetic, environmental or unknown and can result in physical and/or mental impairment. Here is the latest research on birth defects.

Related Papers

Zhonghua kou qiang yi xue za zhi = Zhonghua kouqiang yixue zazhi = Chinese journal of stomatology
Zhi-gang CaiEveley Engel
The Cleft Palate-craniofacial Journal : Official Publication of the American Cleft Palate-Craniofacial Association
S G Gong, R L Eulenberg
© 2022 Meta ULC. All rights reserved