A quantitative model of developmental RTK signaling

Developmental Biology
Yogesh GoyalStanislav Y Shvartsman

Abstract

Receptor tyrosine kinases (RTKs) control a wide range of developmental processes, from the first stages of embryogenesis to postnatal growth and neurocognitive development in the adult. A significant share of our knowledge about RTKs comes from genetic screens in model organisms, which provided numerous examples demonstrating how specific cell fates and morphologies are abolished when RTK activation is either abrogated or significantly reduced. Aberrant activation of such pathways has also been recognized in many forms of cancer. More recently, studies of human developmental syndromes established that excessive activation of RTKs and their downstream signaling effectors, most notably the Ras signaling pathway, can also lead to structural and functional defects. Given that both insufficient and excessive pathway activation can lead to abnormalities, mechanistic analysis of developmental RTK signaling must address quantitative questions about its regulation and function. Patterning events controlled by the RTK Torso in the early Drosophila embryo are well-suited for this purpose. This mini review summarizes current state of knowledge about Torso-dependent Ras activation and discusses its potential to serve as a quantitative model...Continue Reading

Citations

Dec 5, 2019·Proceedings of the National Academy of Sciences of the United States of America·Aleena L PatelStanislav Y Shvartsman
Jan 1, 2020·International Journal of Molecular Sciences·Sarah Mele, Travis K Johnson
Mar 7, 2020·Developmental Cell·Shannon E KeenanStanislav Y Shvartsman
Jan 22, 2021·Molecular Biology of the Cell·Robert A MarmionStanislav Y Shvartsman
May 13, 2021·Stem Cell Reports·Christine Ho, Leonardo Morsut
Jun 25, 2021·Current Biology : CB·Aleena L PatelStanislav Y Shvartsman
Jul 25, 2020·Current Biology : CB·Heath E JohnsonJared E Toettcher

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