PMID: 6805008Jan 1, 1982Paper

A quantitative study in the rat on the relationship between imipramine levels in brain and serum

M van Wijk, J Korf


Serum and brain levels of the tricyclic antidepressant drug imipramine (IMI) were studied in the rat under a variety of conditions. IV doses (range 1 nmol kg-1 to 15 mumol kg-1, 350 ng--5 mg kg-1) and administered 5 min before death, were linearly correlated with IMI levels in serum, frontal cortex, and cerebellum. In this experiment, the highest levels of IMI were achieved in the frontal and occipital cortex and the lowest levels were found in the brain stem. The regional distribution was more even in rats pretreated with thiopental or gamma-hydroxybutyric acid, drugs that alter cerebral blood flow. After 20 min or more, tracer amounts of IMI injected IV to IMI-pretreated rats [1 or 17 days, daily dose 2 x 36 mumol kg-1 (10 mg kg-1), last dose 89 mumol kg-1 (25 mg kg-1), 2--3 h before death] exhibited a distribution pattern in serum and various brain regions similar to that of the unlabeled drug. In the latter experiments, content (per volume) of the tracer or unlabeled IMI was more than 25-fold higher in various brain areas than in serum. It is concluded that despite large differences in drug levels in serum or brain, a close relationship is maintained under the conditions studied.


Jul 31, 1979·Naunyn-Schmiedeberg's Archives of Pharmacology·M Brinkschulte, U Breyer-Pfaff
Sep 13, 1979·Nature·R RaismanS Z Langer
Jul 1, 1979·The International Journal of Applied Radiation and Isotopes·G BergerD Comar
Nov 1, 1977·Journal of Neurochemistry·L I WolfsonL Sokoloff
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Feb 24, 1986·Life Sciences·M A Wilson, E J Roy
Apr 5, 2005·Brain Research·Maura BoldriniVictoria Arango
Dec 1, 1986·The Japanese Journal of Psychiatry and Neurology·K KurataN Yamaguchi
Jan 1, 1987·Clinical and Experimental Hypertension. Part A, Theory and Practice·J S Gutkind, M A Enero
Sep 10, 2010·Basic & Clinical Pharmacology & Toxicology·Iida Peltonen, Pekka T Männistö

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