A quantitative study of sodium tungstate protective effect on pancreatic beta cells in streptozotocin-induced diabetic rats

Micron : the International Research and Review Journal for Microscopy
Z HeidariB Moudi

Abstract

Diabetes is a major public health problem. Development of new therapies that are able to improve glycemia management, cure diabetes, and can even protect from it, are of great interest. This study investigated the protective effect of sodium tungstate against STZ-induced beta-cell damages by means of stereological methods. Sixty rats were divided into six groups: control (C), tungstate-treated control (TC), STZ-induced diabetic (D), STZ-induced diabetic rats were treated by sodium tungstate from 1 week before STZ injection (TDB), food-restricted diabetic (FRD), and diabetic rats treated with sodium tungstate 1 week after STZ administration (TDA). Stereological estimation of pancreas volume, islets volume density, volume-weighted mean islets volume and mass of beta cells, islets, and pancreas and total number of islets were done. Islets volume density, volume-weighted mean islets volume, and mass of beta cells, islets, and pancreas of TDB group was significantly higher than D, FRD and TDA groups (P<0.001) and was comparable to controls (C and TC groups). Total number of islets, pancreas wet weight and volume did not show any significant changes between these groups (P>0.05). Results suggested that sodium tungstate preserves panc...Continue Reading

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Citations

Feb 16, 2013·Molecular Imaging and Biology : MIB : the Official Publication of the Academy of Molecular Imaging·Björn A BlombergAbass Alavi
Jun 26, 2012·Journal of Physiology and Biochemistry·Parichehreh YaghmaeiAzadeh Ebrahim-Habibi
Oct 29, 2014·Diabetes & Metabolism Journal·Chinedum Ogbonnaya EleazuMercy Amarachi Iroaganachi
Dec 30, 2017·International Journal of Experimental Pathology·Joana Noguères SimasSandra Maria Miraglia

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