A quantitative study of spinothalamic neurons in laminae I, III, and IV in lumbar and cervical segments of the rat spinal cord.

The Journal of Comparative Neurology
Khulood Al-KhaterA J Todd

Abstract

The major ascending outputs from superficial spinal dorsal horn consist of projection neurons in lamina I, together with neurons in laminae III-IV that express the neurokinin 1 receptor (NK1r) and have dendrites that enter the superficial laminae. Some neurons in each of these populations belong to the spinothalamic tract, which conveys nociceptive information via the thalamus to cortical areas involved in pain. A projection from the cervical superficial dorsal horn to the posterior triangular nucleus (PoT) has recently been identified. PoT is at the caudal end of the thalamus and was not included in injection sites in many previous retrograde tracing studies. We have injected various tracers (cholera toxin B subunit, Fluoro-Gold, and fluorescent latex microspheres) into the thalamus to estimate the number of spinothalamic neurons in each of these two populations, and to investigate their projection targets. Most lamina I and lamina III/IV NK1r-immunoreactive spinothalamic neurons in cervical and lumbar segments could be labeled from injections centered on PoT. Our results suggest that there are 90 lamina I spinothalamic neurons per side in C7 and 15 in L4 and that some of those in C7 only project to PoT. We found that 85% of t...Continue Reading

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Citations

Nov 12, 2010·Nature Reviews. Neuroscience·Andrew J Todd
Feb 4, 2010·Neuroreport·Earl E CarstensSteven L Jinks
Aug 8, 2009·Science·Yan-Gang SunZhou-Feng Chen
Feb 3, 2012·Physiological Reviews·Hanns Ulrich ZeilhoferGonzalo E Yévenes
Feb 11, 2011·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Qinghao XuTony L Yaksh
Aug 24, 2012·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Najma BaseerAndrew J Todd
Mar 4, 2014·Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan·Masahiro OhsawaHideki Ono
Dec 11, 2013·The Journal of Physiology·Pradeep PunnakkalHanns Ulrich Zeilhofer
Jul 3, 2013·Frontiers in Neuroendocrinology·Åsa Amandusson, Anders Blomqvist
Jun 24, 2015·The Journal of Comparative Neurology·Tasuku AkiyamaE Carstens
Feb 24, 2011·The Journal of Comparative Neurology·Erika PolgárAndrew J Todd
Jun 25, 2010·The Journal of Comparative Neurology·Steve DavidsonGlenn J Giesler
Oct 14, 2009·The Journal of Comparative Neurology·Matilde Cordero-ErausquinYves De Koninck
May 19, 2012·The Journal of Comparative Neurology·Huxing CuiMichael Lutter
Mar 1, 2019·Scientific Reports·Miriam CandelasPierre-François Méry
Feb 6, 2019·The Journal of Physiology·Julien Allard
Jun 24, 2015·Pain·Darren CameronAndrew J Todd
Sep 30, 2017·Annual Review of Physiology·Stephanie C KochMartyn Goulding
Sep 11, 2021·Scientific Reports·Wafa A A AlsulaimanMaria Gutierrez-Mecinas

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