A quantitative trait locus influences coordinated variation in measures of ApoB-containing lipoproteins

Atherosclerosis
David L RainwaterJean W MacCluer

Abstract

Lipoprotein phenotypes are known to be strongly intercorrelated. These intercorrelations are due to genetic and environmental effects on common metabolic pathways. The purpose of this study was to determine if we could localize genes that exert pleiotropic effects on multiple related lipoprotein traits in humans. Using data from the San Antonio Family Heart Study, we extracted principal components from a set of 12 intercorrelated lipoprotein traits that included phenotypes reflecting lipid and protein concentrations and size distributions for LDLs and HDLs. Five principal components were extracted from the data and all were significantly heritable (h(2) = 0.41-0.57). When subjected to linkage analyses, only one, Component 5, returned a LOD score > or = 3 (LOD score was 3.0 at 38cM on chromosome 15; genome-wide P-value = 0.039). LDL median diameter (-0.529), non-HDLC (-0.422), and ApoB (-0.403) concentrations were the only traits with loadings (absolute value) >0.4, suggesting Component 5 is related to LDL size or perhaps more generally to beta-lipoprotein metabolism. Surprisingly, none of the 12 original lipoprotein traits had a LOD >1 in this region of chromosome 15. These data provide evidence for a novel gene, influencing be...Continue Reading

Associated Clinical Trials

References

Jan 15, 1992·Proceedings of the National Academy of Sciences of the United States of America·P M NishinaR M Krauss
Jan 1, 1988·Genetic Epidemiology·K LangeM Boehnke
Feb 1, 1988·Atherosclerosis·I AursnesK Berg
Dec 15, 1988·Clinica Chimica Acta; International Journal of Clinical Chemistry·M BojanovskiH B Brewer
Apr 1, 1987·Proceedings of the National Academy of Sciences of the United States of America·E S Lander, P Green
Dec 1, 1994·Arteriosclerosis and Thrombosis : a Journal of Vascular Biology·K L EdwardsJ V Selby
Jan 1, 1993·Statistical Methods in Medical Research·E Sobel, K Lange
May 1, 1997·Arteriosclerosis, Thrombosis, and Vascular Biology·A G ComuzzieJ W MacCluer
Jan 1, 1997·Journal of Computational Biology : a Journal of Computational Molecular Cell Biology·S C Heath
Apr 3, 1998·American Journal of Epidemiology·K L EdwardsM A Austin
May 23, 1998·American Journal of Human Genetics·L Almasy, J Blangero
Jul 22, 1998·Arteriosclerosis, Thrombosis, and Vascular Biology·D L RainwaterJ L Vandeberg
Nov 4, 1998·American Journal of Epidemiology·R S GrayP J Savage
Jan 26, 1999·Methods in Molecular Biology·D L Rainwater
Jul 3, 1999·Nutrition Reviews·J W MacCluerJ T Williams
Dec 2, 1999·Atherosclerosis·D L Rainwater
Jan 13, 2000·American Journal of Human Genetics·H KnoblauchE Leitersdorf
Apr 14, 2000·American Journal of Human Genetics·B YuanG Schonfeld
Oct 31, 2000·Genetic Epidemiology·J BlangeroL Almasy
Oct 23, 2001·Twin Research : the Official Journal of the International Society for Twin Studies·K L EdwardsM A Austin
Nov 10, 2001·Arteriosclerosis, Thrombosis, and Vascular Biology·D L RainwaterA G Comuzzie
Oct 2, 2002·International Journal of Obesity and Related Metabolic Disorders : Journal of the International Association for the Study of Obesity·T DwyerR Morley

❮ Previous
Next ❯

Citations

Oct 31, 2008·Heredity·D L RainwaterM C Mahaney
Apr 22, 2014·American Journal of Human Genetics·Hugues AschardPeter Kraft
Nov 10, 2004·PLoS Biology·Mathew T PletcherTim Wiltshire
Sep 17, 2005·Arteriosclerosis, Thrombosis, and Vascular Biology·Ronald M Krauss
Sep 1, 2018·Briefings in Bioinformatics·Yan ZhaoHong-Wen Deng

❮ Previous
Next ❯

Related Concepts

Related Feeds

ApoE Phenotypes

Apolipoprotein E (APOE) is a protein involved in fat metabolism and associated with the pathogenesis of Alzheimer's disease and cardiovascular disease. Here is the latest research on APOE phenotypes.

ApoE, Lipids & Cholesterol

Serum cholesterol, triglycerides, apolipoprotein B (APOB)-containing lipoproteins (very low-density lipoprotein (VLDL), immediate-density lipoprotein (IDL), and low-density lipoprotein (LDL), lipoprotein A (LPA)) and the total cholesterol/high-density lipoprotein (HDL) cholesterol ratio are all connected in diseases. Here is the latest research.