A quantitative trait locus influencing anxiety in the laboratory rat

Genome Research
A Fernández-TeruelJonathan Flint

Abstract

A critical test for a gene that influences susceptibility to fear in animals is that it should have a consistent pattern of effects across a broad range of conditioned and unconditioned models of anxiety. Despite many years of research, definitive evidence that genetic effects operate in this way is lacking. The limited behavioral test regimes so far used in genetic mapping experiments and the lack of suitable multivariate methodologies have made it impossible to determine whether the quantitative trait loci (QTL) detected to date specifically influence fear-related traits. Here we report the first multivariate analysis to explore the genetic architecture of rodent behavior in a battery of animal models of anxiety. We have mapped QTLs in an F2 intercross of two rat strains, the Roman high and low avoidance rats, that have been selectively bred for differential response to fear. Multivariate analyses show that one locus, on rat chromosome 5, influences behavior in different models of anxiety. The QTL influences two-way active avoidance, conditioned fear, elevated plus maze, and open field activity but not acoustic startle response or defecation in a novel environment. The direction of effects of the QTL alleles and a coincidence...Continue Reading

References

Nov 1, 1994·Genetics·G A Churchill, R W Doerge
Dec 1, 1996·Nature Genetics·M P MoisanP Mormède
Aug 1, 1997·Behavioral Neuroscience·W A FallsJ F Willott
Nov 14, 1997·Nature Genetics·B CaldaroneL Flaherty
Dec 24, 1997·Genomics·H K Gershenfeld, S M Paul
Jan 7, 1998·Neuroscience and Biobehavioral Reviews·R J Rodgers, A Dalvi
Mar 10, 1998·Neuroscience and Biobehavioral Reviews·A Ramos, P Mormède
Jul 21, 1998·Annals of the New York Academy of Sciences·P DriscollA Tobeña
May 13, 1999·Nature Genetics·T K WatanabeM R James
Jun 9, 2000·Annual Review of Neuroscience·J E LeDoux
Sep 1, 2000·Mammalian Genome : Official Journal of the International Mammalian Genome Society·L C McCarthyM R James
Oct 3, 2000·Genetics·S A Knott, C S Haley
Oct 26, 2000·Proceedings of the National Academy of Sciences of the United States of America·R MottJ Flint
Jan 11, 2000·Nucleic Acids Research·J A BlakeJ A Kadin
Feb 13, 2001·Journal of Affective Disorders·P J LangA Ohman

❮ Previous
Next ❯

Citations

Sep 25, 2004·American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics : the Official Publication of the International Society of Psychiatric Genetics·Benjamin M NealeKenneth S Kendler
Dec 18, 2002·Journal of Neurobiology·Jonathan Flint
Sep 10, 2005·Mammalian Genome : Official Journal of the International Mammalian Genome Society·Bastien LlamasMarie-Pierre Moisan
May 12, 2007·Mammalian Genome : Official Journal of the International Mammalian Genome Society·Christine A PonderAbraham A Palmer
Apr 7, 2007·Bulletin of Experimental Biology and Medicine·L V LoskutovaA L Markel'
Dec 21, 2005·Behavior Genetics·Jan Fullerton
Mar 23, 2004·Behavioural Brain Research·Valeria CarolaFranco Mangia
Jan 14, 2003·Seminars in Cell & Developmental Biology·Jonathan Flint
May 25, 2006·European Journal of Human Genetics : EJHG·Saffron A G Willis-Owen, Jonathan Flint
Aug 24, 2002·The European Journal of Neuroscience·S L LightmanC D Ingram
Aug 17, 2010·Social Neuroscience·Raúl Aguilar
Oct 3, 2008·Behavioural Pharmacology·Jonathan L BrigmanAndrew Holmes
Feb 22, 2005·Genes, Brain, and Behavior·S ZhangH K Gershenfeld
Feb 21, 2007·Genes, Brain, and Behavior·C A PonderA A Palmer
Jul 29, 2010·Genes, Brain, and Behavior·S MartinE D Bel
Jun 26, 2004·Annual Review of Neuroscience·Joshua A Gordon, Rene Hen
Apr 14, 2009·Genetics·Frank W AlbertSvante Pääbo
May 16, 2014·Physiology & Behavior·Lidia ManzoCarmen Torres
Oct 2, 2002·FEBS Letters·Jonathan Flint
May 31, 2003·Stress : the International Journal on the Biology of Stress·R Landgraf, A Wigger
Dec 20, 2011·Behavioural Brain Research·Sira Díaz-MoránAlberto Fernández-Teruel
Oct 5, 2011·Neuroscience Letters·Marta SabariegoFrancisco J Esteban
Sep 28, 2015·Epilepsy & Behavior : E&B·Germain Jean Magloire Ketcha WandaDieudonné Njamen
May 12, 2009·Behavioural Brain Research·Jacenta D AbbottAntonio G Paolini
Apr 22, 2008·Neuroscience and Biobehavioral Reviews·Hymie AnismanJohn D H Stead
May 19, 2007·Pharmacology, Biochemistry, and Behavior·T K BookerAllan C Collins

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.