PMID: 12765975May 27, 2003Paper

A quantitative trait locus on 7q31 for the changes in plasma insulin in response to exercise training: the HERITAGE Family Study

Diabetes
Timo A LakkaHeritage Family Study

Abstract

Several genome-wide linkage scans have been carried out to identify quantitative trait loci for type 2 diabetes and related metabolic phenotypes. However, no previous linkage scans have focused on the response to exercise training of relevant metabolic traits. We performed a genome-wide linkage scan for baseline fasting glucose, insulin, and C-peptide and their responses to a 20-week exercise training program in nondiabetic white and black men and women from the HERITAGE Family Study. In SIBPAL linkage analyses, the maximum number of sibpairs available was 344 and 93 for baseline phenotypes and 300 and 72 for exercise training response phenotypes in whites and blacks, respectively. A total of 509 markers with an average spacing of 6.0 Mb were used. The strongest linkage was found for the changes in fasting insulin in response to exercise training with a marker in the leptin gene on 7q31 (empirical multipoint P = 0.0004) in whites. In blacks, the strongest linkage was observed for baseline fasting glucose on 12q13-q14 (empirical multipoint P = 0.0006). These regions harbor several potential candidate genes. The present findings may be important in identifying individuals at increased risk of developing type 2 diabetes and who ar...Continue Reading

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Citations

Mar 5, 2010·Hybridoma·Hideaki NakamuraMasataka Sugimoto
Jun 8, 2012·Acta Physiologica·J M HagbergE Spangenburg
May 19, 2007·Applied Physiology, Nutrition, and Metabolism = Physiologie Appliquée, Nutrition Et Métabolisme·Gang HuJaakko Tuomilehto
Sep 9, 2004·Medicine and Science in Sports and Exercise·Tuomo RankinenClaude Bouchard
Nov 11, 2006·Medicine and Science in Sports and Exercise·Tuomo RankinenClaude Bouchard
Dec 9, 2015·Endocrine·Anja BöhmHans-Ulrich Häring
Sep 3, 2003·Diabetes/metabolism Research and Reviews
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Jan 27, 2018·Journal of Strength and Conditioning Research·Agata Leońska-DuniecPaweł Cięszczyk
Jul 31, 2004·World Journal of Gastroenterology : WJG·Zhuo LiuFu-De Fang
Apr 18, 2008·The EMBO Journal·Hiroyuki KawagishiMasataka Sugimoto
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Jan 6, 2009·Medicine and Science in Sports and Exercise·Molly S BrayClaude Bouchard
Mar 7, 2019·European Journal of Preventive Cardiology·Martijn Scherrenberg, Paul Dendale

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