A quantitative ultrastructural study of juxtaglomerular arterioles in IDDM patients with micro- and normoalbuminuria

Diabetologia
R OsterbyG C Viberti

Abstract

Hyalinization of juxtaglomerular arterioles is prominent in advanced diabetic nephropathy and may have important functional consequences. We studied the early stages of diabetic renal disease using kidney biopsy material from insulin-dependent diabetic patients, 8 with normal albumin excretion rate (< 15 micrograms/min) and 16 with microalbuminuria (15-200 micrograms/min). Ten living non-diabetic kidney donors served as a control group. Median duration of diabetes was 9.5 years (range 5-31) in patients with normoalbuminuria, and 12 years (7-22) in patients with microalbuminuria (p = 0.27). The tissue was sectioned systematically, 1-micron thick sections for light microscopy at 10-micron intervals, and thin sections for electron microscopy taken at 60-micron intervals. The arterioles were identified as afferent or efferent, and total profiles were photographed (magnification 7500x), providing a systematic independent sample for measurements using standard stereological methods. Patients with microalbuminuria had significantly increased arteriole parameters compared with the control group: for afferent and efferent arterioles the volume fraction of matrix/media, means and (co-efficient of variation, CV), was 0.47 (0.16) vs 0.33 (...Continue Reading

References

Apr 1, 1992·Diabetes Care·UNKNOWN Microalbuminuria Collaborative Study Group
Apr 1, 1991·The Journal of Diabetic Complications·P LaneS M Mauer
Mar 1, 1990·Diabetic Medicine : a Journal of the British Diabetic Association·J L TaftF I Martin
May 1, 1989·Diabetic Medicine : a Journal of the British Diabetic Association·K NørgaardB Feldt-Rasmussen
Jan 1, 1985·Uremia Investigation·C E MogensenB Feldt-Rasmussen
Sep 30, 1993·The New England Journal of Medicine·UNKNOWN Diabetes Control and Complications Trial Research GroupC Siebert

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Citations

Feb 14, 2003·Journal of the Renin-angiotensin-aldosterone System : JRAAS·Per Løgstrup Poulsen
Jan 8, 2009·Journal of the Renin-angiotensin-aldosterone System : JRAAS·Zsolt Razga, Jens Randel Nyengaard
Apr 15, 2003·Journal of the Renin-angiotensin-aldosterone System : JRAAS·Per Løstrup Poulsen
Sep 29, 2000·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·R OsterbyS Rudberg
Jul 2, 2020·International Journal of Nephrology and Renovascular Disease·Zsolt Razga
Apr 26, 2000·American Journal of Physiology. Endocrinology and Metabolism·M W BrandsA E Hailman

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