A quest to understand molecular mechanisms for genetic stability

DNA Repair
Mutsuo Sekiguchi

Abstract

In the midst of the post-war turmoil in Japan, I fortunately followed a path to become a scientist. Sometime at an early stage of my career, I encountered the problem of the cellular response to DNA damage and had the chance to discover a DNA repair enzyme. This event greatly influenced the subsequent course of my research, and I extended my studies toward elucidating the molecular mechanisms of mutagenesis as well as of carcinogenesis. Through these studies I came to understand the importance of mechanisms for dealing with the actions of reactive oxygen species to the living systems. These recollections deal with these endeavors with emphasis on the early part of my scientific career.

References

Jul 1, 1978·Journal of Bacteriology·Y YamamotoN Otsuji
Nov 15, 1992·Proceedings of the National Academy of Sciences of the United States of America·J Y MoM Sekiguchi
Aug 1, 1992·Proceedings of the National Academy of Sciences of the United States of America·M L MichaelsJ H Miller
Jan 1, 1991·Mutation Research·K TakanoM Sekiguchi
Jun 1, 1989·Proceedings of the National Academy of Sciences of the United States of America·M AkiyamaT Horiuchi
Jul 1, 1988·Molecular & General Genetics : MGG·S Shiota, H Nakayama
Sep 1, 1986·Proceedings of the National Academy of Sciences of the United States of America·Y Nakabeppu, M Sekiguchi
May 1, 1985·Proceedings of the National Academy of Sciences of the United States of America·B DempleT Lindahl
Jan 1, 1968·Cold Spring Harbor Symposia on Quantitative Biology·L GrossmanI Mahler
Jan 1, 1968·Cold Spring Harbor Symposia on Quantitative Biology·Y TakagiH Yoshihara
Nov 6, 1969·Biochemical and Biophysical Research Communications·E C Friedberg, J J King
Apr 20, 1967·Biochemical and Biophysical Research Communications·H NakayamaY Takagi
Apr 20, 1967·Biochemical and Biophysical Research Communications·S OkuboY Takagi
Dec 1, 1970·Proceedings of the National Academy of Sciences of the United States of America·S Yasuda, M Sekiguchi
Feb 1, 1966·Proceedings of the National Academy of Sciences of the United States of America·C YanofskyV Horn
Apr 1, 1966·Journal of Molecular Biology·M Sekiguchi
Jul 1, 1982·Nature·K OedaM Sekiguchi
Sep 18, 1980·Nature·B Demple, S Linn
May 1, 1981·Proceedings of the National Academy of Sciences of the United States of America·Y Nakabeppu, M Sekiguchi
Jun 1, 1981·Proceedings of the National Academy of Sciences of the United States of America·T HoriuchiM Sekiguchi
Jan 21, 1997·Proceedings of the National Academy of Sciences of the United States of America·S Shiota, H Nakayama
Feb 7, 1997·The Journal of Biological Chemistry·H IgarashiM Sekiguchi
Jun 6, 1998·Proceedings of the National Academy of Sciences of the United States of America·H KawateM Sekiguchi

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Citations

Dec 1, 2006·Proceedings of the Japan Academy. Series B, Physical and Biological Sciences·Mutsuo Sekiguchi

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