PMID: 15248837Jul 14, 2004Paper

A questionnaire survey concerning the most favourable treatment for Graves' disease in children and adolescents

European Journal of Endocrinology
Gerasimos E Krassas, Zvi Laron

Abstract

Graves' disease (GD) is the most common cause of juvenile thyrotoxicosis in children and adolescents (1, 2). Three treatment modalities are now available for the treatment of Graves' thyrotoxicosis in childhood: antithyroid drugs (ATD), surgery and radioactive iodine (RAI). However, none of these treatments has been shown to be ideal or clearly superior to the others. Physicians in different countries have different approaches concerning the optimal treatment of juvenile GD. In a European questionnaire study (3), which was conducted by the European Thyroid Association in 1993 and in which 99 individuals or groups from 22 countries participated, it was found that 22 out of 99 physicians from nine countries would consider RAI treatment as the treatment of choice for children with recurrent thyrotoxicosis after surgery, or with recurrent thyrotoxicosis 2 years after ATD. However, RAI is preferred by only a small percentage of physicians for this group of patients in Europe. Hardly any of the respondents chose RAI for the patients with a toxic adenoma or a multinodular toxic goiter (3). On the other hand, in view of the difficulties with medical therapy in children and adolescents, including poor compliance, a high rate of relapse,...Continue Reading

Citations

Aug 21, 2004·Nuclear Medicine Communications·Ujjal K Mallick, Haris Charalambous
Aug 1, 2015·Journal of Pediatric Endocrinology & Metabolism : JPEM·Diana StaffordPaul Kaplowitz
Jan 21, 2011·Endocrine Practice : Official Journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists·Ayse Pinar CemerogluAlan T Davis
Feb 13, 2008·Pediatrics·Nicole S GlaserUNKNOWN Organization of Pediatric Endocrinologists of Northern California Collaborative Graves' Disease Study Group

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